Expanding its Us in Lupus effort, GlaxoSmithKline (GSK) has planned “Night of Beauty” events to reach women of color, a group disproportionately affected by this disease. Us in Lupus is a 12-week online community and education program for new lupus patients. The upcoming events are extending support to…
Adding low-dose interleukin-2 (IL-2) to standard therapy increases responses and complete remission of lupus nephritis in patients with systemic lupus erythematosus (SLE), results of a randomized clinical trial suggest. Patients on IL-2 had higher proportions of regulatory T cells, a subset of immune T cells associated with…
Apellis Pharmaceuticals has decided to stop the development of an experimental therapy known as APL-2 for lupus nephritis and primary membranous nephropathy after the completion of an ongoing Phase 2 clinical trial. The open-label Phase 2 DISCOVERY trial (NCT03453619) is testing APL-2 in four kidney…
Despite limited evidence that opioids reduce pain in people with rheumatic diseases, a study has found that nearly one in three adults with systemic lupus erythematosus (SLE) use prescription opioids for pain control, with two-thirds of them using these medications for longer than one year. The study, “…
Positive early Phase 1 clinical data in healthy volunteers support Kangpu Biopharmaceuticals’ plan to advance KPG-818 into clinical trials in patients with systemic lupus erythematosus (SLE) or blood cancers. KPG-818 is a small molecule designed to inhibit the activity of the CRL4-CRBN protein complex. CRBN, or cereblon, is a…
Taking vitamin D supplements does not improve bone health in people with systemic lupus erythematosus (SLE), at least in the short-term, a small clinical trial suggests. The study, “Effect of vitamin D on serum markers of bone turnover in SLE in a randomised controlled trial,”…
People with systemic lupus erythematosus (SLE) have vitamin D deficiency — and living in Asia, South America, or Africa are among the risk factors, according to a review study. Not receiving vitamin D supplements also is a risk factor increasing this deficiency, the findings showed. The research, “…
Patients with systemic lupus erythematosus (SLE) who attain a low disease state have a lower risk of subsequent disease flares and accumulated organ damage, making this state a potential treatment target in clinical trials, a new study suggests. The research was published in an article, “Lupus low disease…
Low-dose use of a treatment for certain advanced cancers, aldesleukin, was well-tolerated and lessened disease activity in people with refractory systemic lupus erythematosus (SLE) taking part in a small Phase 1/2a trial. Study results also showed patients had higher proportions of a subset of immune T-cells associated with suppression…
In support of projects in several areas of lupus research, the Lupus Foundation of America has awarded four investigators — two more  than in prior years — with the Gary S. Gilkeson Career Development Award (CDA). The award is meant for fellows and clinicians at the early stages of…