An enzyme called fumarate hydratase is involved in the control of the inflammatory activity of macrophages, a type of immune cell with a central role in driving inflammatory disorders like lupus, researchers report. “No-one has made a link from Fumarate Hydratase to inflammatory macrophages before and we feel that…
New measures are needed to assess disease severity in lupus in clinical trials, a study highlights. One important goal in developing such measures is to include patient-reported outcomes — which, according to the study authors, are now not used in most clinical trials assessing the effectiveness of new treatments.
A urine test that can be performed at home showed good accuracy in detecting lupus nephritis, a form of lupus marked by kidney damage, in a recent study. This test, which works with a smartphone app, “could potentially accelerate early detection of renal involvement or disease flares in lupus patients,…
The U.S. Patent and Trademark Office (USPTO) has allowed Aurinia Pharmaceuticals submit a new patented method of using Lupkynis (voclosporin), its approved oral treatment for lupus nephritis. The new application (No. 17/713,140), titled, “Improved Protocol for Treatment of Lupus Nephritis,” covers a method of using Lupkynis in combination with…
The approvals of new medications in the last few years have dramatically shifted the treatment landscape for lupus nephritis, a severe manifestation of lupus characterized by kidney inflammation, with a sharp drop found in the use of rituximab. That’s according to the market research group Spherix Global Insights,…
Blocking CD71, a protein that cells use to import iron, reduced the disease-driving inflammatory activity of immune cells in preclinical models of systemic lupus erythematosus (SLE), a new study shows. The study, “Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus,” was…
Treatment with cenerimod showed promising trends toward reducing disease activity in systemic lupus erythematosus (SLE), especially in people with more severe disease, according to data from a Phase 2b clinical trial. The therapy’s developer, Idorsia Pharmaceuticals, announced the launch of a Phase 3 trial program to further explore cenerimod’s…
Lupkynis (voclosporin) has been approved in Great Britain as a treatment for adults with active lupus nephritis by the U.K.’s Medicines and Healthcare products Regulatory Agency (MHRA), Aurinia Pharmaceuticals, the therapy’s developer, announced. The MHRA’s approval came just a few months after the European Commission approved Lupkynis…
The U.S. Food and Drug Administration (FDA) has agreed to allow Kyverna Therapeutics to begin clinical testing of KYV-101, the company’s investigational cell therapy for lupus nephritis, a form of lupus that causes kidney damage. Kyverna submitted a request, in the form of an investigational new drug…
Kyverna Therapeutics has submitted an investigational new drug (IND) application asking regulators for permission to begin clinical testing on KYV-101, an experimental cell therapy for lupus nephritis — a severe manifestation of lupus that causes kidney damage. The company is actively working with sites in the U.S. and…