A new public-private initiative brings academic and industry researchers from 15 European countries together in a large-scale effort to understand differences and commonalities in seven immune-mediated and inflammatory diseases, including systemic lupus erythematosus (SLE), to better predict a patient’s response to treatment and likely disease progression. The project, called 3TR (for…
Positive early Phase 1 clinical data in healthy volunteers support Kangpu Biopharmaceuticals’ plan to advance KPG-818 into clinical trials in patients with systemic lupus erythematosus (SLE) or blood cancers. KPG-818 is a small molecule designed to inhibit the activity of the CRL4-CRBN protein complex. CRBN, or cereblon, is a…
In support of projects in several areas of lupus research, the Lupus Foundation of America has awarded four investigators — two more than in prior years — with the Gary S. Gilkeson Career Development Award (CDA). The award is meant for fellows and clinicians at the early stages of…
PredictImmune is planning to expand its pipeline with the development of new strategies to support personalized care for people with systemic lupus erythematosus (SLE) and other inflammatory diseases. This follows the U.K.-based company’s acquisition of worldwide licensing rights over Cambridge Enterprise’s algorithms and software. The new deal…
A Phase 2a clinical trial evaluating Resolve Therapeutics‘ investigational treatment RSLV-132 in systemic lupus erythematosus (SLE) has completed patient enrollment, the company announced. The trial has recruited 64 patients with active skin disease and are positive for RNA antibodies. Patients were recruited at 20 centers in the United…
The Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) — a tool commonly used to determine disease activity in systemic lupus erythematosus patients — misses nearly two of out three patients with clinically meaningful changes in disease activity, a Portuguese study found. The study, “Performance of SLEDAI-2K…
APVO210, an antibody to treat autoimmune and inflammatory diseases such as lupus, has entered a Phase 1 clinical trial to test its safety and tolerability in healthy volunteers, announced its developer Aptevo Therapeutics. Conducted in Australia, the study (NCT03768219) is meant to determine APVO210’s optimal dose and regimen for…
The U.S. Patent and Trademark Office (USPTO) is issuing a new patent to Aurinia Pharmaceuticals covering a method of use and dosing protocol of the immunosuppressant voclosporin in patients with lupus nephritis. The patent (No. 15/835,219), titled “Protocol for Treatment of Lupus Nephritis” covers an individualized treatment protocol where…
High levels of a protein called HER2 in the urine can help identify children and adolescents with lupus who are at risk of serious kidney complications, a study suggests. While the study is still ongoing, the finding suggests that the use of approved HER2 inhibitors such as Tyverb (lapatinib)…
Aurinia Pharmaceuticals has completed patient enrollment for its Phase 3 trial that will assess the potential of voclosporin as an add-on to standard treatment regimens in patients with lupus nephritis, the company announced. The enrollment phase was finished ahead of schedule and exceeded expectations, recruiting more participants…