Posts by: Patricia Inacio, PhD

News

Re-engineering a class of immune cells called dendritic cells (DCs) toward self-tolerance for many of the antigens underlying systemic lupus erythematosus (SLE) may be a potential therapeutic approach to treat ... Read more

July 18, 2017

Stem Cell Therapy Fails to Improve Lupus Patients’ Kidney Impairment, Study Shows

News

Umbilical cord-derived stem cells failed to improve lupus patients’ impaired kidney function, according to a small clinical trial in China whose results contrasted with previous studies. The research, “A ... Read more

July 10, 2017July 10, 2017

Study Identifies Several Predictors of Poor Pregnancy Outcomes in Women with Lupus

News

A study has identified several predictors of poor pregnancy outcomes in women with lupus, including disease flares less than six months before conception and use of immunosuppressants. The research, ... Read more

June 9, 2017June 9, 2017

Benlysta Improves SLE Outcomes, Canadian OBSErve Study Shows

News

Patients with systemic lupus erythematosus (SLE) showed clinically significant improvement and a significant decrease in their use of anti-inflammatory glucocorticoids after six months of treatment with Benlysta (belimumab), the Canadian OBSErve study showed. ... Read more

May 3, 2017May 3, 2017

Discovery of New Molecular Mechanism Inhibiting Autoantibody Production May Aid in Lupus Research

News

Portuguese researchers discovered a new cellular mechanism that may explain how lupus and other autoimmune diseases develop. Their study, “T follicular helper and T follicular regulatory cells have different ... Read more

March 31, 2017March 31, 2017

Lupus Research Alliance Picks the Top 10 Innovative Projects It Will Fund

News

The Lupus Research Alliance has chosen its Novel Research Grant Class of 2017, which consists of 10 projects that represent innovative approaches in lupus-treatment development. “Standing on a 16-year foundation of ... Read more

March 9, 2017March 9, 2017

Small Molecule LA1 Suppresses Inflammation, Improves Renal Function in SLE Patients

News

Scientists at Chicago’s Rush University Medical Center have discovered a small molecule that can significantly ameliorate symptoms in systemic lupus erythematosus (SLE) patients who carry a defective CD11b protein. The findings ... Read more

February 21, 2017February 21, 2017

Immune-system Gene Variations May Increase Risk of Lupus in Caucasians, Study Reports

News

Certain variations in immune-system genes may be associated with an increased risk of Caucasians developing systemic lupus erythematosus (SLE), according to a study The research, “Association between C4, C4A, ... Read more

February 14, 2017February 14, 2017

Mitochondria Protein Triggers Immune Response in Lupus Patients, Study Reports

News

Reactive oxygen species in cells’ mitochondria trigger an immune response widely detected in patients with lupus, researchers have discovered. The finding suggests the potential for a new therapeutic avenue to ... Read more

February 2, 2017February 2, 2017

Higher Lupus Incidence in Asians Linked to Two Novel Genetic Variations

News

Novel genetic variations known as single nucleotide polymorphisms (SNPs) are associated with a higher incidence of systemic lupus erythematosus (SLE) in Asians, research shows. The study, “Evaluation of 10 SLE susceptibility ... Read more