In a new study entitled “TWEAK/Fn14 Signaling Involvement in the Pathogenesis of Cutaneous Disease in the MRL/lpr Model of Spontaneous Lupus” researchers identified a new signaling pathway, mediated by the cytokine TWEAK and its receptor Fn14, which promotes chronic skin inflammation in a mouse model of cutaneous lupus erythematosus.
In a new study entitled “The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity,” researchers identified a new molecule – TREML4 – that promotes TLR7-mediated release of inflammatory cytokines in systemic lupus erythematosus. The study was published in the journal Nature…
In a recent study entitled “Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephritis based on clinical and histopathological outcome following induction therapy,” researchers suggest two novel biomarkers for treatment outcome and renal disease in patients with Lupus nephritis. The study…
Researchers at the Center for Clinical and Translational Science, Ohio State University developed the first chimeric mouse model to study Sjögren’s syndrome, an autoimmune disorder. Notably, this new mouse model will also allow researchers to study the human characteristics of other autoimmune diseases,…
In a new study entitled “Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN,” researchers discovered a key pathway that protects healthy tissue against an exacerbated and deleterious immune response. The study was published in the Journal of the American…
A new case study entitled “Acute kidney injury associated with minimal change disease in systemic lupus erythematosus: a case report” describes a rare case of a patient with Systemic lupus erythematosus and acute kidney injury associated with minimal change disease. The study was published in the Journal…