In a new study entitled “T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection” researchers discovered how T-cell exhaustion can determine the outcome of autoimmune diseases, suggesting that therapeutics targeting the underlying mechanism of T-cell exhaustion can benefit patient outcomes in diseases like systemic lupus erythematosus. The…
In a new study entitled “Tumor necrosis factor-alpha single nucleotide polymorphisms in juvenile systemic lupus erythematosus” researchers investigated genetic variants, specifically those known as single nucleotide polymorphisms, within the gene tumor necrosis factor-alpha (TNF-a), a potent pro-inflammatory cytokine that was previously suggested to play a role in juvenile…
Researchers at Monash University’s Department of Immunology recently developed a method to prevent lupus by targeting a specific receptor in B cells. B cells are a key type of immune cell responsible for defending the body against infections, producing antibodies and generating memory B cells that remain in the body so that, if encountering…
Several research teams at the New York University School of Medicine – Langone Medical Center recently presented their latest discoveries on key clinical aspects of Systemic Lupus Erythematosus at the NYU Seminar in Advanced Rheumatology. In a study entitled Preventive Approach to Congenital Heart Block with Hydroxychloroquine (PATCH)…
In a new study entitled “TWEAK/Fn14 Signaling Involvement in the Pathogenesis of Cutaneous Disease in the MRL/lpr Model of Spontaneous Lupus” researchers identified a new signaling pathway, mediated by the cytokine TWEAK and its receptor Fn14, which promotes chronic skin inflammation in a mouse model of cutaneous lupus erythematosus.
In a new study entitled “The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity,” researchers identified a new molecule – TREML4 – that promotes TLR7-mediated release of inflammatory cytokines in systemic lupus erythematosus. The study was published in the journal Nature…
In a recent study entitled “Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephritis based on clinical and histopathological outcome following induction therapy,” researchers suggest two novel biomarkers for treatment outcome and renal disease in patients with Lupus nephritis. The study…
Researchers at the Center for Clinical and Translational Science, Ohio State University developed the first chimeric mouse model to study Sjögren’s syndrome, an autoimmune disorder. Notably, this new mouse model will also allow researchers to study the human characteristics of other autoimmune diseases,…
In a new study entitled “Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN,” researchers discovered a key pathway that protects healthy tissue against an exacerbated and deleterious immune response. The study was published in the Journal of the American…
A new case study entitled “Acute kidney injury associated with minimal change disease in systemic lupus erythematosus: a case report” describes a rare case of a patient with Systemic lupus erythematosus and acute kidney injury associated with minimal change disease. The study was published in the Journal…