Author Archives: Patricia Inacio, PhD

Targeting T-cell Exhaustion As a Therapy For Lupus Patients

In a new study entitled “T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection” researchers discovered how T-cell exhaustion can determine the outcome of autoimmune diseases, suggesting that therapeutics targeting the underlying mechanism of T-cell exhaustion can benefit patient outcomes in diseases like systemic lupus erythematosus. The…

Genetic Variants Identified In TNF Gene of Patients with Juvenile Systemic Lupus Erythematosus

In a new study entitled “Tumor necrosis factor-alpha single nucleotide polymorphisms in juvenile systemic lupus erythematosus” researchers investigated genetic variants, specifically those known as single nucleotide polymorphisms, within the gene tumor necrosis factor-alpha (TNF-a), a potent pro-inflammatory cytokine that was previously suggested to play a role in juvenile…

New Potential Lupus Drug Targets B Cell Receptor

Researchers at Monash University’s Department of Immunology recently developed a method to prevent lupus by targeting a specific receptor in B cells. B cells are a key type of immune cell responsible for defending the body against infections, producing antibodies and generating memory B cells that remain in the body so that, if encountering…

New Candidate Biomarkers Discovered for Patients With Lupus Nephritis

In a recent study entitled “Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephritis based on clinical and histopathological outcome following induction therapy,” researchers suggest two novel biomarkers for treatment outcome and renal disease in patients with Lupus nephritis. The study…