In a new study entitled “Association of BAFF, APRIL serum levels, BAFF-R, TACI and BCMA expression on peripheral B-cell subsets with clinical manifestations in systemic lupus erythematosus” researchers investigated the role of B cells’ cytokines and receptors in the pathogenesis and development of systemic lupus erythematosus (SLE). The…
In a recent study entitled “Systemic lupus erythematosus complicated by diffuse alveolar haemorrhage: risk factors, therapy and survival” researchers performed the first study investigating the risk factors for diffuse alveolar haemorrhage in systemic lupus erythematosus and how it impacts patients’ therapy responses and outcomes. The study was published…
In a recent study entitled “Hyperactivation and in situ recruitment of inflammatory Vδ2 T cells contributes to disease pathogenesis in systemic lupus erythematosus” scientists discovered that the biggest human γδ T cell subset, the Vδ2 T cells present in peripheral blood, are key mediators of tissue injury…
Lupus is an autoimmune disease, i.e., a disease where the immune system attacks the person’s own body, and it manifests via different symptoms (a key factor frequently delaying the correct diagnosis). Currently without any cure, worldwide experts (from over 80 countries) are meeting in Vienna, Austria, from the 2nd –…
In a new study entitled “Treatment of systemic lupus erythematosus patients with the BAFF antagonist “peptibody” blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials” authors determined the safety, tolerability and efficacy of blisibimod, a B cell-activating factor antagonist, in patients with systemic…
In a new study entitled “Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice” researchers revealed a potential new therapy against the root-cause of systemic lupus erythematosus. The study was published in the journal…
In a new study entitled “Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis“ a team of scientists showed that upon injury, kidney cells activate a cellular process, the epithelial-to-mesenchymal transition (EMT), which ultimately leads to fibrosis in the kidneys. The research team performed…
In a new study entitled “Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus” researchers identified that epigenetic modifications in the DNA, specifically DNA methylation, is associated with autoantibody production in systemic lupus erythematosus. The study was published in the open-access journal…
In a recent study entitled “Autoimmune Disease in First-Degree Relatives and Spouses of Individuals With Celiac Disease” researchers show that first-degree relatives and spouses of individuals with celiac disease have an increased risk of suffering from other type of autoimmune diseases, such as systemic lupus erythematosus. The study…
In a new study entitled “T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection” researchers discovered how T-cell exhaustion can determine the outcome of autoimmune diseases, suggesting that therapeutics targeting the underlying mechanism of T-cell exhaustion can benefit patient outcomes in diseases like systemic lupus erythematosus. The…