Equillium announced that it is planning to test EQ001, its monoclonal antibody, in a Phase 1b trial as a potential therapy for patients with refractory lupus nephritis, among the most frequent and severe manifestations of lupus and one that can progress to kidney failure. “Our decision to explore EQ001 for…
Aiming to distill the latest in a record number of ongoing global research in lupus, the Lupus Foundation of America (LFA) has created a new digital resource called Inside Lupus Research. The dedicated online source for research updates is hosted on the Foundation’s website. Designed for patients…
Eliminating B-cells using a recent form of immunotherapy that employs genetically modified T-cells is able to treat lupus in mice in a stable and efficient way, a study funded by Lupus Research Alliance shows.
Dressed in signature purple attire or accessories, more than 350 lupus advocates from around the U.S. came together on Capitol Hill earlier this month to urge Congress to earmark more funds for lupus research and education. As part of the Lupus Foundation of America’s 2019 National Lupus Advocacy…
High blood pressure and a skin condition characterized by a netlike pattern of reddish-blue skin discoloration — livedo reticularis — may be risk factors for peripheral nervous system manifestations in systemic lupus erythematosus (SLE), a retrospective study suggests. The study, “Peripheral nervous system involvement in systemic…
The Lupus Research Alliance and its affiliate, Lupus Therapeutics, have partnered with Takeda Pharmaceutical to conduct a Phase 1 clinical trial testing Takeda’s investigational antibody TAK-079 for the treatment of systemic lupus erythematosus (SLE) patients. The trial (NCT03724916), which will include approximately 24 participants across the U.S., is for patients with…
Physical fitness, particularly muscle strength and cardiorespiratory fitness, are associated with better quality of life scores in women with systemic lupus erythematosus (SLE), a study reports. The study, “Association of physical fitness components and health-related quality of life in women with systemic lupus erythematosus with mild disease activity,” was…
Researchers have identified a previously unknown mechanism by which cells that are infected can signal their neighbors that something is wrong. Understanding how this alarm signal works might lead to new strategies for shutting down harmful immune reactions in diseases like lupus. The study, “Intracellular bacteria engage…
A frailty index developed by the Systemic Lupus International Collaborating Clinics (SLICC) could be a powerful and meaningful health measure to estimate vulnerability and mortality risk among patients with systemic lupus erythematosus (SLE), a study has found. The study, “Evaluating the properties of a frailty index and its association with…
An abnormal mix of bacteria in the gut, particularly increases in the bacteria Ruminococcus gnavus, may play a critical role in systemic lupus erythematosus (SLE), a study shows. The study, “Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal,” was published in …