GlaxoSmithKline’s Benlysta reduced lupus patients’ need for higher doses of corticosteroids, a therapy that is beneficial but causes long-term organ damage, an additional analysis of Phase 3 clinical trial results shows. In addition, a combination of Benlysta and corticosteroids reduced patients’ organ damage more than corticosteroids alone over five years, two extensions…
Obese women with systemic lupus erythematosus (SLE) have a poorer quality of life and suffer more symptoms than women of normal weight, according to new research presented at the 2017 ACR/ARHP Annual Meeting in San Diego. The study, “Obesity Independently Associates with Worse Patient Reported Outcomes in Women with Systemic…
Janssen announced that its investigational antibody Stelara (ustekinumab) showed positive results in a Phase 2 trial as a therapy for patients with systemic lupus erythematosus (SLE). Based on these results, the company said it would further test Stelara in a Phase 3 development program planned for 2018. The study, “Efficacy and…
Nimbus Therapeutics, which uses computer analysis to identify and develop therapies for autoimmune diseases like lupus, has established a long-term strategic alliance with Celgene, a company that focuses on immunology. The agreement promises to foster the development of new therapies for diseases triggered by imbalanced immune system responses. Nimbus…
Patients with systemic lupus erythematosus (SLE) report high levels of satisfaction when Benlysta (belimumab) therapy was self-administered using an autoinjector, a small study reports. The study, “Patient Evaluation of Satisfaction and Outcomes with an Autoinjector for Self-Administration of Subcutaneous Belimumab in Patients with Systemic Lupus Erythematosus,” was published in…
Certain autoantibodies may help identify the small group of patients with systemic lupus erythematosus (SLE) at risk of developing pulmonary arterial hypertension (PAH), and those who are at lower risk of death, according to the findings of a retrospective French study. The research, “Pulmonary Arterial Hypertension Associated…
Lupus is more prevalent among Hispanic and Asian women in Manhattan, and those women develop significantly greater organ complications, particularly kidney disease, a study from the NYU School of Medicine shows. The research, “The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New…
A large group study following almost 1 million people for more than six years shows that patients with autoimmune diseases, including systemic lupus erythematosus (SLE), have a significantly greater risk for cardiovascular disease and death. The research, “The Association Between Chronic Immune-Mediated Inflammatory Diseases and Cardiovascular Risk,”…
The survival rates of adults and children with systemic lupus erythematosus (SLE) has not increased in the past 20 years, according to the results of a systematic review and meta-analysis. The study, “Survival in adults and children with systemic lupus erythematosus: a systematic review and Bayesian meta-analysis…
A new study suggests that the protein Nogo-a, known to limit the recovery of neurons after injury, is involved in the development of neurophsychiatric lupus (NPSLE).