Phase 3 trials of ianalumab for SLE, lupus nephritis now enrolling

Three new Phase 3 clinical trials testing the experimental therapy ianalumab in people with systemic lupus erythematosus (SLE) and lupus nephritis are now recruiting patients. All three trials are being sponsored by Novartis, the company developing ianalumab. Lupus Therapeutics, the clinical research affiliate of the Lupus Research Alliance,…

1st patient enrolled in global Phase 2 trial of daxdilimab for lupus

A Phase 2 trial evaluating the safety and efficacy of daxdilimab, a potentially first-in-class treatment for people with active, proliferative lupus nephritis (LN) — a lupus complication marked by kidney damage — has enrolled its first patient. Horizon Therapeutics, the therapy’s developer, anticipates about 210 patients, ages 18–80,…

Phase 4 Study of Acthar Gel Enrolls First SLE Patients with Active Disease

Mallinckrodt Pharmaceuticals announced the enrollment of the first patients in the company’s Phase 4 clinical trial of H.P. Acthar Gel (repository corticotropin injection) for the treatment of systemic lupus erythematosus (SLE) patients with persistently active disease. The randomized and double-blind study (NCT02953821) will assess the effectiveness of the gel against…