The activity of a class of immune signaling proteins known as type I interferons — called IFN-1 — was markedly high in the bloodstream of people with systemic lupus erythematosus (SLE) before treatment, a study reported. Such elevated IFN-1 activity was not seen in patients with various other autoimmune…
The first patient has been enrolled in RECAST DLE, a Phase 2 study evaluating daxdilimab, a potentially first-in-class therapy for moderate-to-severe discoid lupus erythematosus (DLE), a form of lupus that affects the skin. Horizon Therapeutics, the therapy’s developer, expects to enroll about 100 DLE patients, ages 18–75 whose…
Kira Pharmaceuticals will test KP-104, an investigational therapy for a blood-clotting disorder associated with systemic lupus erythematosus (SLE), using KORU Medical Systems’ easy-to-use subcutaneous (under-the-skin) Freedom System infusion device. “We selected KORU Medical based on their track record of helping patients receive high-value therapeutics subcutaneously in the…
Using clinical data collected over time, two machine learning computer models were found to accurately predict inpatient hospitalization due to systemic lupus erythematosus (SLE) — the most common form of lupus. One method was most accurate in using short-term clinical assessment data to foretell future hospitalizations, while the other…
A specific protein subunit — called GluN2A — found in a critical nerve cell receptor is the target of autoantibodies that cause neuron loss and cognitive difficulties in a mouse model of systemic lupus erythematosus (SLE), a study shows. Blocking GluN2A…
Treatment with Acthar Gel (repository corticotropin injection) may ease exacerbations and symptoms in people with systemic lupus erythematosus (SLE) and other inflammatory disorders, a real-world study reports. About 95% of those with SLE showed benefits, as rated by physicians. The study, “…
Early studies of an endocannabinoid-based treatment for cutaneous lupus erythematosus (CLE) showed that it eased skin lesions, according to Hoth Therapeutics, which developed the therapy. Endocannabinoids are cannabis-like molecules naturally produced by the human body, with effects…
People with systemic lupus erythematosus (SLE) who received more quality clinical care report lower disease activity, slower accumulation of disease-related damage, and a higher physical health-related quality of life, a study finds. The analysis identified parameters that led to improved self-reported health outcomes,…
Using glucocorticoids to treat inflammation in systemic lupus erythematosus (SLE) was associated with organ damage in patients without active disease, a large study found. These findings draw attention to the possible harmful effects of glucocorticoids — a type of corticosteroid hormone —…