A Phase 2b clinical trial assessing Neovacs’ investigational immunotherapy for the treatment of systemic lupus erythematosus (SLE) is on schedule to deliver results by mid-2018, the company recently said. The announcement follows an independent review board’s fourth and final evaluation of the trial, signing off on safety and other considerations,…

Inhibition of a natural enzyme that works as a sensor for virus and bacteria invasions may reduce inflammation associated with autoimmune diseases, including systemic lupus erythematosus, according to a recent study. The findings, reported in the study “Small molecule inhibition of cGAS reduces interferon expression in primary macrophages…

French pharmaceutical firm Neovacs has completed enrollment for a Phase 2b clinical trial (IFN-K-002) to evaluate the efficacy and safety of IFNα-Kinoid to treat systemic lupus erythematosus (SLE). “The completion of enrollment is an important milestone for our IFN Kinoid program and confirms the interest of leading clinicians conducting our trial in this novel…

Large-scale analysis of genome-wide gene expression signatures allows researchers to discriminate between patients with active and inactive systemic lupus erythematosus — and could help physicians in adjusting treatment to control disease activity while minimizing the risk of side effects. The study reporting the method, “Clinical Application of a Modular…

Many studies have established that patients with autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren’s syndrome, and systemic lupus erythomatosus (SLE) have an increased risk for developing another autoimmune disease, but why this happens is still not fully understood. In a recent news report that presented data from multiple studies addressing the…

Texas researchers found that neutrophils, a type of immune cell, release oxidized mitochondrial DNA, triggering immune reactions in systemic lupus erythematosus (SLE). The findings provide insights into key disease mechanisms, which might be employed in the development of new therapies for this complex and devastating disease. The research team at…

Researchers at Genentech and the University of Michigan recently revealed that a biomarker assay to assess the interferon signature in patients with systemic lupus erythematosus (SLE) is associated with serological features of the disease. The study was published in the journal Lupus Science & Medicine and…

A recently published study in the new issue of Science by a team of investigators from the University of Texas Southwestern Medical Center (UTSMC), is leading to a better understanding of the innate immune system, which plays an integral role in the development of abnormal…