A team of researchers has identified new variations within the coding region of genes — which gives rise to proteins — that may be associated with a person’s susceptibility to systemic lupus erythematosus (SLE). The study, “Exome-wide association study identifies four novel loci for systemic lupus erythematosus…
The PRKCB gene is significantly more expressed in lupus patients than in healthy controls, a new Chinese study shows. But the gene appears to have a protective role, as patients with higher PRKCB expression have lower disease activity scores. The research, “Increased expression of PRKCB mRNA in peripheral blood mononuclear…
Corbus Pharmaceuticals recently started a Phase 2 clinical trial evaluating anabasum as an investigational therapy for the treatment of systemic lupus erythematosus (SLE). Anabasum is a synthetic endocannabinoid mimetic drug, meaning it mimics the action of endocannabinoids, which are endogenous molecules that bind to cannabinoid receptors in the nervous system. The drug…
Patients with systemic lupus erythematosus (SLE) have higher incidence of subclinical atherosclerosis markers compared to heathy people, a French study shows. Understanding how cardiovascular disease develops in lupus patients may help establish better, personalized therapeutic strategies, including in patients who have no history of cardiovascular disease. The study, “…
Pulmonary hypertension affects 8 percent of patients with systemic lupus erythematosus (SLE), a new meta-analysis shows. But pulmonary hypertension (PH) does not affect all lupus patients equally. A subgroup analysis showed that men, adults, and non-Asian patients are the most affected by the disease. The study, “Prevalence of pulmonary…
The Lupus Multi-Cultural Engagement Partnership (Lupus MCEP) was recently launched at an inaugural meeting in New York City to address the need to increase the number of participants in upcoming lupus clinical trials and to guarantee that ethnic and racial representation is considered. The Lupus MCEP meeting was…
Older patients with systemic lupus erythematosus (SLE) have a low risk of future renal involvement, researchers report. The risk factors they identified with lupus nephritis onset included young age, low complement levels, and non-Caucasian ethnicity. The study, “Predictors of incident proteinuria among patients with SLE,” was published…
The Oklahoma Medical Research Foundation (OMRF) recently launched the world’s first lupus prevention study, known as the SMILE clinical trial. The Phase 2 study (NCT03030118) seeks to identify individuals at high risk for developing lupus and treat them with an immune-modifying medication before they develop the disease. The overarching…
Researchers at Northwell Health’s Feinstein Institute for Medical Research have launched a clinical trial to evaluate the potential of a small electronic device in relieving pain in lupus patients. “Lupus is a painful disease, notoriously hard to diagnose and difficult to treat – new treatment options are desperately needed,” Cynthia…
Abnormal levels of microRNA in the blood of lupus nephritis patients could help doctors diagnose the kidney disorder and scientists develop therapies for it, a study reports. MicroRNA helps genes regulate the production of proteins and other substances. The study, “Profiling analysis of circulating microRNA in peripheral…