Author Archives: Ashraf Malhas, PhD

Researchers Identify Potential New Target for Treating Lupus Nephritis

Researchers identified a new player involved in the development of lupus nephritis, providing potentially new therapeutic intervention points. The protein, iRhom2, is part of a pathway that, until now, could not be blocked due to its role in other essential functions. But targeting iRhom2 retained its healthy functions while preventing kidney damage.

Mixed Connective Tissue Disease Shows Milder Activity than Other Rheumatic Disorders, Study Finds

Mixed connective tissue disease (MCTD), a chronic disorder that has overlapping features of two or more systemic rheumatic disorders, is a relatively stable disease that is milder than systemic lupus erythematosus and systemic sclerosis, new research from Norway shows. However, most patients failed to achieve long-term remission. The study, “Disease evolution…

SLE Patients with Pulmonary Arterial Hypertension Have ‘Relatively Good’ Survival Rates, Study Shows

A retrospective study shows that 83.9 percent of patients suffering from systemic lupus erythematosus (SLE) and pulmonary arterial hypertension survive at least five years after diagnosis. Also, those with anti-U1-RNP antibodies tend to have better survival rates, the study shows. The research, “Pulmonary Arterial Hypertension Associated With Systemic Lupus Erythematosus:…