A type of immune cell that protects against viruses and cancer may worsen systemic lupus erythematosus (SLE) and trigger disease flares, a recent study with mice suggests. Led by researchers at the U.K.’s Imperial College London, the study, “C1q restrains autoimmunity and viral infection by…
Hemogenyx Pharmaceuticals and Rockefeller University recently agreed to collaborate on developing new treatments for lupus using the biotechnology company’s humanized mouse models. Hemogenyx, which is focused on developing new, more effective methods of bone marrow or blood stem cell transplants for blood diseases, will use its modeling…
To help raise awareness of lupus nephritis on World Lupus Day, Aurinia Pharmaceuticals announced some new efforts dedicated to giving patients with the disease an opportunity to connect and share their experiences. The company is collaborating with The Mighty, a digital health community that features stories written by…
The Phase 1b trial evaluating NKTR-358 — an investigational therapy that stimulates regulatory T-cell activation — in systemic lupus erythematosus (SLE) has begun dosing patients, Nektar Therapeutics announced. Unlike immunosuppressive therapies that dampen the entire immune system, and are associated with potentially serious side effects, NKTR-358 was designed to restore the…
Results of a large-scale international survey, released by the World Lupus Federation on World Lupus Day May 10, show a low level of lupus awareness by the general public, revealing a need for increased education and understanding about the disease. Lupus is considered to be a global health problem, with more than…
Lupus remains a poorly known or understood disease, with a recent poll by the Lupus Foundation of America finding 51 percent of respondents worldwide did not even know it is a disease — and one that affects an estimated five million people worldwide. Because such lack of awareness can extent…
Systemic lupus erythematosus (SLE) is a major cause of death in young women that goes largely unrecognized due to its exclusion from an annual nationwide ranking, a new U.S. study shows. Based on these findings, researchers believe that public health and research programs dedicated to the disease are warranted, and…
A new mechanism that helps to maintain immune self-tolerance and prevent autoimmune diseases was discovered using human cells and mice, new research shows. The findings identify a novel pathway that regulates tolerance in B-cells, which may provide a new diagnostic marker and therapeutic targets to…
The Lupus Research Alliance and its newly formed affiliate Lupus Therapeutics will collaborate with Bristol-Myers Squibb (BMS) to test a novel investigational candidate BMS-986165 as a potential therapy for lupus. BMS-986165 is the first of its kind to be tested in lupus. The medicine is a potent,…
Teen and young women with systemic lupus erythematosus (SLE) have a higher risk of adverse pregnancy-related outcomes, including hypertensive disorders, maternal death, preterm birth, spontaneous abortion, and induced abortion, according to researchers. Their study, “Adverse pregnancy outcomes in adolescents and young women with systemic lupus erythematosus: a…