Lupus Flares May Be Linked to Damage to Mitochondria, Study Reports
Excessive production of type I interferon (IFN-I) — a molecule that mediates immune and inflammatory responses — in people with systemic lupus erythematosus (SLE) may be caused by small fragments of mitochondrial DNA (mtDNA) that are released upon damage, a study suggested. The study, “VDAC oligomers…