Women with systemic lupus erythematosus (SLE) whose disease went into remission right before becoming pregnant show better outcomes in the post-partum period, including a lower flare rate, according to a two-year follow up study. These findings highlight how “planned pregnancy counseling is fundamental when managing SLE patients,” the researchers wrote.
News
Belimumab continues to show a favorable risk-benefit profile in adults with systemic lupus erythematosus (SLE), according to safety data from six clinical trials. Researchers noted the findings “add to the evidence base supporting a positive benefit-risk profile of belimumab in the treatment of adult patients with SLE.” Data from…
The Lupus Foundation of America (LFA) has honored scientists Eric Morand and Joyce Chang for notable contributions to lupus research. Morand, PhD, of Monash University received the Evelyn V. Hess Award, and Chang, MD, of Boston Children’s Hospital and Harvard Medical School, was honored with the Mary Betty…
Reduced lymphatic drainage might explain why skin reactions to sunlight, or photosensitivity, may lead to systemic immune reactions and overall disease flareups in people with systemic lupus erythematosis (SLE), a study suggests. Data showed that the flow of the skin’s lymphatic fluid — which sends cells and molecular signals to…
The U.S. Food and Drug Administration (FDA) has agreed to allow Kyverna Therapeutics to begin clinical testing of KYV-101, the company’s investigational cell therapy for lupus nephritis, a form of lupus that causes kidney damage. Kyverna submitted a request, in the form of an investigational new drug…
Kira Pharmaceuticals will test KP-104, an investigational therapy for a blood-clotting disorder associated with systemic lupus erythematosus (SLE), using KORU Medical Systems’ easy-to-use subcutaneous (under-the-skin) Freedom System infusion device. “We selected KORU Medical based on their track record of helping patients receive high-value therapeutics subcutaneously in the…
When given on top of standard therapy, zetomipzomib led to clinically significant reductions in urine protein levels, a marker of kidney impairment, in systemic lupus erythematosus (SLE) patients with active lupus nephritis, a severe form of lupus that causes kidney damage. That’s according to full data from the now…
To help dermatologists and nephrologists understand the importance of minority participation in lupus clinical trials and why such participation is lacking, the American College of Rheumatology (ACR) is announcing new continuing medical education (CME) offerings. Specifically, the new CME provides the specialists with information about racial disparities in…
A CAR T-cell therapy targeting disease-driving immune cells safely led to sustained disease remission for five people with systemic lupus erythematosus (SLE) who’d previously failed to respond to other treatments, a recent study reported. Treatment was also highly specific, preventing autoimmune activity, but didn’t impair general immune system…
Kyverna Therapeutics has submitted an investigational new drug (IND) application asking regulators for permission to begin clinical testing on KYV-101, an experimental cell therapy for lupus nephritis — a severe manifestation of lupus that causes kidney damage. The company is actively working with sites in the U.S. and…
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