Patients with systemic lupus erythematosus (SLE) display a wide range of symptoms and disease activity. Accordingly, there are a variety of therapeutic regimens designed for them. Each has its own mechanism of action, but often times patients experience the same clinical relief of symptoms. This can confound the clear choice…
A research team has recently showed that the natural product astilbin can diminish disease development in mice susceptible to lupus by decreasing functional activated T and B cells. The study entitled “Decrease of Functional Activated T and B Cells and Treatment of Glomerulonephitis in Lupus-Prone Mice Using a Natural Flavonoid…
Paris, France based Neovacs, a biotech firm specializing in active immunotherapies for treating autoimmune diseases, has announced establishment of a wholly-owned U.S. subsidiary, Neovacs, Inc., which is headquartered in Boston and incorporated in Delaware. Creation of a U.S. subsidiary is an important strategic step for Neovacs in extending clinical initiatives…
This year’s edition of the New York Lupus Handbag Luncheon gathered over 350 people in a fundraising effort to help support research on the chronic disease lupus last Monday, April 13. The event, which is organized annually by both the S.L.E. Lupus Foundation and the Lupus Research Institute (LRI), included prominent…
Several research teams at the New York University School of Medicine – Langone Medical Center recently presented their latest discoveries on key clinical aspects of Systemic Lupus Erythematosus at the NYU Seminar in Advanced Rheumatology. In a study entitled Preventive Approach to Congenital Heart Block with Hydroxychloroquine (PATCH)…
Researchers at Genentech and the University of Michigan recently revealed that a biomarker assay to assess the interferon signature in patients with systemic lupus erythematosus (SLE) is associated with serological features of the disease. The study was published in the journal Lupus Science & Medicine and…
Padlock Therapeutics, a firm focused on the development of new treatment alternatives for autoimmune conditions, recently announced a collaboration with three different research institutes specialists in protein-argenine deiminase (PAD) enzymes and their effect on disease pathogenesis, including Systemic Lupus Erythematosus (SLE). Padlock will work directly with the University of…
Researchers at the Northwestern University Feinberg School of Medicine in Chicago recently characterized the risk of progression from discoid lupus erythematosus (DLE) to systemic lupus erythematosus (SLE) in children, and the disease phenotype. The study entitled “The natural history of pediatric-onset discoid lupus erythematosus” was published in…
In a new study entitled “TWEAK/Fn14 Signaling Involvement in the Pathogenesis of Cutaneous Disease in the MRL/lpr Model of Spontaneous Lupus” researchers identified a new signaling pathway, mediated by the cytokine TWEAK and its receptor Fn14, which promotes chronic skin inflammation in a mouse model of cutaneous lupus erythematosus.
In a new study entitled “The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity,” researchers identified a new molecule – TREML4 – that promotes TLR7-mediated release of inflammatory cytokines in systemic lupus erythematosus. The study was published in the journal Nature…
