Several research teams at the New York University School of Medicine – Langone Medical Center recently presented their latest discoveries on key clinical aspects of Systemic Lupus Erythematosus at the NYU Seminar in Advanced Rheumatology. In a study entitled Preventive Approach to Congenital Heart Block with Hydroxychloroquine (PATCH)…
Researchers at Genentech and the University of Michigan recently revealed that a biomarker assay to assess the interferon signature in patients with systemic lupus erythematosus (SLE) is associated with serological features of the disease. The study was published in the journal Lupus Science & Medicine and…
Padlock Therapeutics, a firm focused on the development of new treatment alternatives for autoimmune conditions, recently announced a collaboration with three different research institutes specialists in protein-argenine deiminase (PAD) enzymes and their effect on disease pathogenesis, including Systemic Lupus Erythematosus (SLE). Padlock will work directly with the University of…
Researchers at the Northwestern University Feinberg School of Medicine in Chicago recently characterized the risk of progression from discoid lupus erythematosus (DLE) to systemic lupus erythematosus (SLE) in children, and the disease phenotype. The study entitled “The natural history of pediatric-onset discoid lupus erythematosus” was published in…
In a new study entitled “TWEAK/Fn14 Signaling Involvement in the Pathogenesis of Cutaneous Disease in the MRL/lpr Model of Spontaneous Lupus” researchers identified a new signaling pathway, mediated by the cytokine TWEAK and its receptor Fn14, which promotes chronic skin inflammation in a mouse model of cutaneous lupus erythematosus.
In a new study entitled “The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity,” researchers identified a new molecule – TREML4 – that promotes TLR7-mediated release of inflammatory cytokines in systemic lupus erythematosus. The study was published in the journal Nature…
Researchers at The Feinstein Institute for Medical Research in Manhasset, New York recently published in the journal Lupus Science & Medicine their finding on two predictors of neuropsychological dysfunction in individuals with systemic lupus erythematosus (SLE). The study is entitled “Brain metabolism and…
Breakthroughs in new treatments for lupus may be useless if patients do not have access to innovative therapies as a consequence of their high costs or regulatory restrictions, a point raised the Lupus Foundation of America in a statement published on the organization’s website. The president and CEO of the Lupus…
In a recent study entitled “Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephritis based on clinical and histopathological outcome following induction therapy,” researchers suggest two novel biomarkers for treatment outcome and renal disease in patients with Lupus nephritis. The study…
Mallinckrodt Pharmaceuticals recently announced two presentations during the 2015 Spring Clinical Meetings of the National Kidney Foundation (NKF) showing independent reports of positive results with the H.P. Acthar Gel in proteinuria’s remission. Proteinuria (excess of protein in urine) is linked to the nephrotic syndrome, which is characterized…