News

Lupkynis approved in Switzerland to treat adults with lupus nephritis

Lupkynis (voclosporin) is now approved in Switzerland to treat adults with active lupus nephritis, a complication of lupus characterized by kidney damage and inflammation. The approval specifically covers the treatment, given along immunosuppressants, for adults with active class 3, 4, and 5 lupus nephritis — three subtypes of the…

Toni Braxton partners with Aurinia on kidney care campaign for lupus

Toni Braxton is hoping to strike a chord with people with lupus via Aurinia Pharmaceuticals‘ “Get Uncomfortable” campaign: the singer-songwriter wants to empower fellow patients to prioritize kidney health as a key part of their care. Braxton, a Grammy Award-winning singer, and an actress, producer, and entrepreneur, was…

7 lupus research projects win LRA Innovation Award grants

Seven projects led by research teams from the U.S. and Europe have been announced as the recipients of the latest round of Lupus Research Alliance (LRA) Lupus Innovation Award (LIA) grants, which can total up to $300,000. The awards provide support — up to $150,000 annually for two…

Phase 1/2 trial of relma-cel, a CAR T-cell therapy, to open in China

JW Therapeutics has received approval from Chinese authorities to open a clinical trial of its CAR T-cell therapy, relmacabtagene autoleucel (relma-cel), in systemic lupus erythematosus (SLE) patients with moderate-to-severe and treatment-resistant active disease. Although not approved for SLE or other autoimmune disorders, relma-cel is available under the…

CMV viral infections in SLE children linked to poor outcomes

Viral infections with cytomegalovirus, known as CMV, are highly prevalent in children with systemic lupus erythematosus (SLE), and are linked to high disease activity and poor outcomes, a study in China reports. Given that anti-CMV treatment can reduce disease activity and flares, the virus’ early identification and treatment…

Long-term safety of Lupkynis for SLE confirmed in AURORA trial

Over 18 months, the approved therapy Lupkynis (voclosporin) lessened inflammation and prevented further kidney damage in systemic lupus erythematosus (SLE) patients with active lupus nephritis, without any signs of kidney-related toxicity seen with similar treatments. New top-line data show participants in the Lupkynis treatment arm of the now…

Cabaletta’s CAR T-cell therapy cleared for SLE Phase 1/2 trial

The U.S. Food and Drug Administration (FDA) has cleared a Phase 1/2 clinical trial to test CABA-201, Cabaletta Bio’s investigational CAR T-cell therapy, in people with systemic lupus erythematosus (SLE) with or without kidney involvement. Cabaletta asked to launch the trial in the form of an investigational new…