No safety concerns seen one month after dosing with KYV-101 for lupus

No signs of neurotoxicity were seen for 28 days after the first patient in a Phase 1 clinical trial was dosed with KYV-101, Kyverna Therapeutics’ investigational cell therapy for lupus nephritis, a lupus complication marked by kidney damage. A standard 4-week post-infusion observation period in such clinical trials is…

Long-term safety of Lupkynis for SLE confirmed in AURORA trial

Over 18 months, the approved therapy Lupkynis (voclosporin) lessened inflammation and prevented further kidney damage in systemic lupus erythematosus (SLE) patients with active lupus nephritis, without any signs of kidney-related toxicity seen with similar treatments. New top-line data show participants in the Lupkynis treatment arm of the now…

KPG-818 Found Safe to Enter Clinical Trials for SLE, Blood Cancers

Positive early Phase 1 clinical data in healthy volunteers support Kangpu Biopharmaceuticals’ plan to advance KPG-818 into clinical trials in patients with systemic lupus erythematosus (SLE) or blood cancers. KPG-818 is a small molecule designed to inhibit the activity of the CRL4-CRBN protein complex. CRBN, or cereblon, is a…

Rituxan Reduces Lupus Patients’ Steroid Use, Study Shows

Treating newly diagnosed systemic lupus erythematosus patients with Rituxan (rituximab) is safe and effective, according to a study that followed a small group of patients over several years. A key finding was that Rituxan reduced the patients’ use of corticosteroids, which is good news because long-term steroid use can cause numerous…

Merck to Present Positive Phase 2 Data on Atacicept, Potential SLE Therapy, at ACR 2016

Merck KGaA announced that it will present two posters showing positive clinical data for its drug candidate atacicept, a recombinant fusion protein for the treatment of systemic lupus erythematosus (SLE). The presentations will take place at the 2016 American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting in Washington, D.C., which opens on Friday and runs through…