Daily moderate exercise suppresses lupus-associated kidney inflammation while social stress worsens it, researchers at Ohio State University have found. Their study, “Daily Moderate Exercise Is Beneficial and Social Stress Is Detrimental to Disease Pathology in Murine Lupus Nephritis,” appeared in the journal Frontiers in Physiology.
Interferon-gamma, an endogenous regulator of immune responses, is associated with reduced cerebral volume in lupus patients, a new Brazilian study shows. The study, “Interferon-γ Is Associated with Cerebral Atrophy in Systemic Lupus Erythematosus,” appeared…
Researchers have devised a blood test that predicts which blood relatives of patients with systemic lupus erythematosus (SLE) — people who are at high risk of developing the disease — will actually develop it, even seven years before the disease declares itself. The blood test can be used to provide preventive…
Neovacs will present an update on the company’s interferon alpha (IFNα) Kinoid vaccine program for lupus, dermatomyositis and type 1 diabetes at the upcoming 2017 Keystone Symposia Conference taking place in Banff, Alberta, Canada. Géraldine Grouard-Vogel, PhD, the company’s chief scientific officer, is set to give the presentation — “Overexpression of IFNalpha…
China has issued a patent for Neovacs’ interferon alpha (IFNα) vaccine for diseases characterized by over-expression of the cytokine IFNα, including lupus, dermatomyositis and type 1 diabetes. The patent, together with others Neovacs has obtained, give the company global protection for the vaccine until at least 2032. Neovacs’ technology targets…
The Phase 2b clinical trial evaluating interferon-alpha (IFNα) Kinoid, Neovacs’ immunotherapy candidate for the treatment of systemic lupus erythematosus (SLE), received a positive interim data review from the Independent Data and Safety Monitoring Board (IDSMB) overseeing the study. The randomized, multicenter and international clinical trial (NCT02665364) is evaluating the biological…
Blocking a protein that controls the immune system’s reaction to a virus may also be used to prevent autoimmune reactions in diseases such as systemic lupus erythematosus, research indicates. Although the PLSCR1 protein was discovered in the brain, researchers are exploring its role in inflammatory diseases throughout the body. An…
Researchers are learning how signals about disease-related inflammatory activity are sent from the body to the brain — insight that could lead to manipulating nerves to treat autoimmune conditions such as systemic lupus erythematosus. A team at the Feinstein Institute for Medical Research in New York discovered that different immune…
Measuring the level of certain pro-inflammatory cytokines in the blood of patients with systemic lupus erythematosus (SLE) may help to identify those patients with kidney inflammation (nephritis), and so that treatments can begin that might halt the progression to kidney failure. The study, “Serum Cytokines Th1, Th2, and…
Researchers have identified novel biomarkers for lupus nephritis (LN), a disease that affects several patients with systemic lupus erythematosus (SLE), according to a study published in the journal Arthritis & Rheumatology. The authors reported these biomarkers can accurately indicate disease development and predict therapeutic effectiveness. The study is titled “…