Sanofi will work with ImmuNext to develop INX-021, a CD40L monoclonal antibody designed to suppress overactive cell signals associated with autoimmune disorders, including lupus and multiple sclerosis. Under the agreement, Sanofi will have an exclusive license to further develop and commercialize INX-021, a synthetic antibody from ImmuNext that is now in preclinical…
Vaccinating systemic lupus erythematosus (SLE) patients with attenuated T-cells improved their symptoms, according to results of a small controlled trial. It supported previous findings that the vaccination can help lupus patients. The study, “The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation,” was…
A retrospective study of lupus myocarditis (LM) in systemic lupus erythematosus (SLE) patients found that, while the disease initially is severe, its long-term outcomes generally are very good. The results were published in the Journal of Rheumatology in the article, “Lupus…
Systemic lupus erythematosus (SLE) patients with signs of organ damage when first hospitalized, even if they don’t have active disease, are likely to have poorer outcomes, researchers in China reported. Mortality risk was particularly high in SLE patients with neuropsychiatric and cardiopulmonary complications or with evidence of kidney failure. But…
Researchers are learning how signals about disease-related inflammatory activity are sent from the body to the brain — insight that could lead to manipulating nerves to treat autoimmune conditions such as systemic lupus erythematosus. A team at the Feinstein Institute for Medical Research in New York discovered that different immune…
Researchers analyzed blood samples from systemic lupus erythematosus (SLE) patients and found supportive evidence that SLE enhances anemia by promoting the suicidal death of red blood cells. The study “Eryptosis as an Underlying Mechanism in Systemic Lupus Erythematosus-Related Anemia” was published in the journal Cellular Physiology and Biochemistry.
You’ve probably heard of the book 50 Shades of Grey and you’ve more than likely figured out that it is code for “50 Shades of F’ed Up.” Interestingly enough, that phrase truly describes my being diagnosed and having to live with lupus. Every day is a different shade of…
Most lupus patients who added Benlysta (belimumab) to their treatment regimen improved, according to research in Germany. Seventy-eight percent of the systemic lupus erythematosus (SLE) patients in the study showed improved health after six months of Benlysta treatment, doctors said. In addition, 42 percent of patients reported feeling better.
Aurinia Pharmaceuticals and Lonza have entered into a long-term manufacturing agreement over the active pharmaceutical ingredient (API) in voclosporin, Aurinia’s investigative drug for diseases that include lupus nephritis (LN). The agreement aims toward providing an eventual commercial supply of voclosporin, and includes its use in an upcoming and possibly pivotal clinical trial in LN…
Researchers have uncovered genetic differences explaining why autoimmune diseases, such as systemic lupus erythematosus, affect women more than men. And opposed to what earlier research suggested, the mechanisms are unrelated to sex hormones. The findings indicate that it may be crucial for scientists to study male and female disease separately.