The discovery of a factor that acts as a brake on the immune system’s first line of defense may lead to new strategies for fighting autoimmune diseases such as systemic lupus erythematosus, a study reports. The factor could also impact research into antiviral therapies, vaccine adjuvants, and cancer immunotherapies. An adjuvant…
Urinary levels of the protein albumin may help determine the amount of kidney damage in lupus nephritis patients who exhibit few symptoms, according to a study. The finding could help doctors decide which patients need a kidney biopsy. The study, “Urinary Albumin Levels Are Independently Associated With Renal Lesion…
Children with systemic lupus erythematosus (SLE) may be prone to develop infections, especially bacterial pneumonia, according to a new study. Also, the risk of infection was higher among African American and Native American children, children with lupus nephritis and other health conditions, and those under corticosteroid treatment. The findings were…
Meso Scale Discovery (MSD) has developed a biochemical testing platform that can detect biomarkers involved in autoimmune diseases like systemic lupus erythematosus (SLE). The V-PLEX platform can detect the biomarkers IL-17A, IL-21, IL-22, IL-23, IL-27, and MIP-3α in human cell culture supernatants, or liquids, in the blood components plasma and serum,…
Evaluating heart function using an electrocardiogram (ECG) can be a useful noninvasive tool for early detection of patients with systemic lupus erythematosus (SLE) who have an increased risk for cardiovascular disease (CVD), researchers found. The study, “Prevalence and associated factors of resting electrocardiogram abnormalities among systemic lupus erythematosus patients without…
Neovacs and BioSense Global will jointly develop an interferon alpha (IFNα) vaccine to treat lupus and dermatomyositis in China. News of the commercial licensing agreement, worth up to €65 million, comes just days after Chinese authorities issued a patent for Neovacs’ IFNα vaccine (IFNα Kinoid) for diseases characterized by over-expression of the cytokine…
Certain variations in immune-system genes may be associated with an increased risk of Caucasians developing systemic lupus erythematosus (SLE), according to a study The research, “Association between C4, C4A, and C4B copy number variations and susceptibility to autoimmune diseases: a meta-analysis,” was published in Scientific Reports. The immune system…
Women with systemic lupus erythematosus (SLE) had more frequent miscarriages and other pregnancy complications than those with rheumatoid arthritis (RA) or healthy women, according to a recent study. SLE women also used fewer contraceptives, leading to more unplanned pregnancies that greatly increased the risk of complications for both mothers and babies. The Sri Lankan…
A test that Exagen Diagnostics developed to help doctors control levels of a lupus therapy in patients’ blood has been endorsed by a company that supports arthritis and rheumatology practitioners around the United States, Exagen announced. American Arthritis and Rheumatology Associates (AARA) powered by Bendcare also endorsed an Exagen blood test for rheumatoid arthritis.
Voclosporin, a drug being developed to treat lupus nephritis (LN), appears to be safe for patients regardless of ethnicity, according to a Phase 1 clinical trial conducted in healthy Japanese, Aurinia Pharmaceuticals reports. The treatment also has a good pharmacokinetic (PK) and pharmacodynamic (PD) profile. PK refers to the body’s reaction to a drug…