People with systemic lupus erythematosus (SLE) are more prone to developing metabolic syndrome — a cluster of metabolic and cardiovascular risk factors that include hypertension, obesity, poor glucose tolerance, and high levels of cholesterol and triglycerides, like fat, in the blood — than others, new study reports, noting the syndrome as a likely cause of heart disease…
TxCell will do two presentations in Boston on its use of computer simulations to pack the most punch into the gene therapy it has developed against the kidney disease lupus nephritis and other autoimmune disorders. The immunotherapy approach involves engineering patients’ own regulatory T-cells, or CAR-Tregs, to ward off the diseases. The…
The patient engagement platform Inspire has partnered with the Lupus Foundation of America to launch LupusConnect, an online community that allows lupus patients and their families and friends to share experiences, emotional support, and tips to help people manage daily struggles from the disease.
Genes found in African-Americans with systemic lupus erythematosus (SLE) may explain why they have a higher risk of atherosclerosis, a heart disease in which fatty deposits can clog arteries. The study arriving at that conclusion, “Apolipoprotein L1 risk variants associate with prevalent atherosclerotic disease in African American systemic…
A large group study following almost 1 million people for more than six years shows that patients with autoimmune diseases, including systemic lupus erythematosus (SLE), have a significantly greater risk for cardiovascular disease and death. The research, “The Association Between Chronic Immune-Mediated Inflammatory Diseases and Cardiovascular Risk,”…
Levels of distinct immune cells, including certain monocyte subsets, are altered in systemic lupus erythematosus (SLE) patients, research from China indicates. The new study, “Upregulation of CD16- monocyte subsets in systemic lupus erythematous patients,” appeared in the journal Clinical Rheumatology. The research was led…
A new study from Harvard University has discovered some of the mechanisms behind why and how immune cells attack their own body in autoimmune diseases such as systemic lupus erythematosus (SLE). The study titled, “Clonal Evolution of Autoreactive…
A Brazilian study makes a connection between income, lupus progression and lupus outcomes. The less income a person has, the more likely that their disease will progress faster and that they will have a poor outcome, according to the research, which confirmed a California study’s results. Other factors that the…
Interferon-gamma, an endogenous regulator of immune responses, is associated with reduced cerebral volume in lupus patients, a new Brazilian study shows. The study, “Interferon-γ Is Associated with Cerebral Atrophy in Systemic Lupus Erythematosus,” appeared…
The survival rates of adults and children with systemic lupus erythematosus (SLE) has not increased in the past 20 years, according to the results of a systematic review and meta-analysis. The study, “Survival in adults and children with systemic lupus erythematosus: a systematic review and Bayesian meta-analysis…