The protein OX40L, produced by immune B-cells, plays a key role in the development of systemic lupus erythematosus (SLE) by activating a T-cell subset involved in autoimmunity, new research has found. Inhibition of OX40L B-cells improved lupus symptoms in mice, suggesting that OX40L is a promising new target for lupus treatment. The…
Uptravi (selexipag) delays the progression of pulmonary arterial hypertension in people with PAH that is associated with connective tissue diseases, including lupus, a Phase 3 clinical trial shows. Patients also tolerate Uptravi well, researchers said. PAH associated with connective tissue disease is also known as PAH-CTD, and PAH associated with lupus…
A 49-year-old woman with severe demyelinating syndrome systemic lupus erythematosus (DS-SLE), where lupus affects the white matter in the brain, was successfully treated with Genentech‘s Rituxan (rituximab), along with other medications. The case report, “Severe neuropsychiatric systemic lupus erythematosus successfully treated with rituximab: an alternative to…
Lupus is more prevalent among Hispanic and Asian women in Manhattan, and those women develop significantly greater organ complications, particularly kidney disease, a study from the NYU School of Medicine shows. The research, “The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New…
Sufficient scientific evidence exists to support the switch from bio-originators to biosimilars to treat rheumatic diseases, concluded a task force of experts from 10 countries. Their study, “Consensus-based recommendations for the use of biosimilars to treat rheumatological diseases,” appeared in Annals of the Rheumaetic Diseases.
The Montreal Cognitive Assessment (MoCA) may be a useful clinical tool for screening cognitive impairment in patients with systemic lupus erythematosus (SLE), a new study shows. The study titled, “Performance of Screening Tests for Cognitive Impairment in Systemic Lupus Erythematosus,” was published in the…
A Chicago nursing student with lupus has won Top Products‘ 2017 Single Mother Scholarship. The winner, Tiffani Topps, is attending Chicago State University. Top Products, a website that helps people find quality product and service reviews online, created the scholarship to honor moms whose success stories defy the odds. Growing up…
People with systemic lupus erythematosus (SLE) are more prone to developing metabolic syndrome — a cluster of metabolic and cardiovascular risk factors that include hypertension, obesity, poor glucose tolerance, and high levels of cholesterol and triglycerides, like fat, in the blood — than others, new study reports, noting the syndrome as a likely cause of heart disease…
TxCell will do two presentations in Boston on its use of computer simulations to pack the most punch into the gene therapy it has developed against the kidney disease lupus nephritis and other autoimmune disorders. The immunotherapy approach involves engineering patients’ own regulatory T-cells, or CAR-Tregs, to ward off the diseases. The…
The patient engagement platform Inspire has partnered with the Lupus Foundation of America to launch LupusConnect, an online community that allows lupus patients and their families and friends to share experiences, emotional support, and tips to help people manage daily struggles from the disease.