Treatment with 150 mg atacicept significantly improves outcomes in systemic lupus erythematosus (SLE) patients with high disease activity, data from a Phase 2b clinical trial show. The results of the trial were presented recently at the 2018 SLEuro Annual Meeting in Dusseldorf, Germany in a poster titled “SRI response,…
A new test looking at the presence of 26 autoantibodies — antibodies targeting a person’s own healthy proteins — is better at diagnosing systemic lupus erythematosus (SLE) and predicting its course than conventional ones, a study shows. The test was developed using several newly identified autoantibodies for SLE, and groups…
A Phase 2 clinical trial testing a Corbus Pharmaceuticals’ synthetic cannabinoid derivative – lenabasum (JBT-101) – for lupus patients is underway. The therapy has no psychotropic properties and is intended to treat joint inflammation associated with lupus. If proven effective, it may offer patients a…
Harmless bacteria that live in the skin, mouth and gut may trigger autoimmunity in people who are genetically disposed to it, according to a study with lupus implications. This means that targeting what scientists call commensal bacteria could be a way to development treatments for lupus and other autoimmune diseases,…
Treatment with atacicept — a protein that targets the immune system — significantly reduced disease flares in patients with systemic lupus erythematosus (SLE), data from EMD Serono‘s Phase 2 trial shows. The study, “Reduction of systemic lupus flares by atacicept in a randomized, placebo- controlled,…
Zhijian “James” Chen, PhD recently was awarded the 2018 Lurie Prize in Biomedical Sciences by the Foundation for the National Institutes of Health (FNIH) for his discovery of how DNA stimulates immune responses, potentially causing autoimmune diseases like lupus. The Lurie Prize in Biomedical Sciences will be presented to…
Top-line results of ImmuPharma’s Phase 3 clinical trial testing Lupuzor (rigerimod) as a systemic lupus erythematosus (SLE) treatment are expected by mid-April, according to the company. ImmuPharma also announced that database lock of the trial is expected by April 6. This milestone prevents unauthorized or unintended alterations to…
Suppressing the key inflammatory protein iRhom2 reduced inflammation and prevented kidney scarring in mice susceptible to developing lupus, a study suggests. This approach could be the basis of new treatments for kidney damage in patients with lupus and other autoimmune diseases, researchers believe. The study, “iRhom2 promotes…
New York scientists have come up with a new way to measure electric signals in the major nerve running from the head to the abdomen — a discovery that could improve diagnosis and treatment of inflammatory diseases like lupus. The team at the Feinstein Institute for Medical Research used mice to do…
GSK is starting a Phase 3 trial of Benlysta (belimumab) in combination with Rituxan (rituximab) for treating patients with systemic lupus erythematosus (SLE). The ability of the combination to provide sustained disease control or remission will be tested. Benlysta is the only approved biological medication…