People with systemic lupus erythematosus (SLE) have vitamin D deficiency — and living in Asia, South America, or Africa are among the risk factors, according to a review study. Not receiving vitamin D supplements also is a risk factor increasing this deficiency, the findings showed. The research, “…
Low-dose use of a treatment for certain advanced cancers, aldesleukin, was well-tolerated and lessened disease activity in people with refractory systemic lupus erythematosus (SLE) taking part in a small Phase 1/2a trial. Study results also showed patients had higher proportions of a subset of immune T-cells associated with suppression…
The Committee for Medicinal Products for Human Use (CHMP), an arm of the European Medicines Agency (EMA), recommended the approval of Benlysta (belimumab) as an add-on therapy for children age 5 and older with systemic lupus erythematosus (SLE) and high disease activity. The European Commission will…
Reactivation of the Epstein-Barr virus (EBV) may result in systemic lupus erythematosus (SLE) in at-risk individuals, according to a study in relatives of SLE patients. The findings also revealed that gene variants previously associated with EBV infection are implicated in the risk of developing SLE. The research, “…
Adding anifrolumab to standard-of-care treatment led to a clinically meaningful reduction in disease activity at week 52 in patients with systemic lupus erythematosus (SLE), according to top-line results of a Phase 3 trial. The TULIP 2 study (NCT02446899) assessed the safety and efficacy of AstraZeneca’s anifrolumab in…
Pregnancy outcomes in women with systemic lupus erythematosus (SLE) have improved significantly in the past two decades, including a marked decrease in maternal mortality, according to a large U.S. study. The research, “Trends in Maternal and Fetal Outcomes Among Pregnant Women With Systemic Lupus Erythematosus in…
Treatment with the investigational vaccine IFN-alpha Kinoid increased the number of systemic lupus erythematosus (SLE) patients achieving low disease activity, lessened their use of corticosteroids, and was well-tolerated, according to full results of a Phase 2b trial. The findings, “IFN Kinoid in Systemic Lupus Erythematosus (SLE):…
In patients with recent-onset systemic lupus erythematosus (SLE), higher levels of a protein called osteopontin seem to be associated with lupus nephritis and more disease activity, but not with the development of organ damage over five years, according to a study. The study, “Osteopontin and Disease…
Vaccinated patients with highly active systemic lupus erythematosus seem to lose their immunity levels over time, a study in rubella-vaccinated adolescents suggests. The study, “Risk factors associated with accelerated rubella-IgG antibody loss in previously vaccinated, treatment-naïve juvenile Systemic Lupus Erythematosus patients: a prospective study,” was published in the…
Neovacs and Centurion Pharma will continue the joint development of the investigational vaccine IFNalpha Kinoid for people with systemic lupus erythematosus (SLE) based on the positive results of a Phase 2b clinical study. The two companies had signed a licensing agreement in July 2017, establishing a…