Author Archives: Jose Marques Lopes, PhD

Top 10 Lupus Stories of 2018

Throughout 2018, Lupus News Today brought you coverage of important discoveries, potential disease markers, treatment developments, and clinical trials related to lupus. As we look forward to reporting more news to patients, family members, and caregivers in 2019, here are the Top 10 most-read articles of 2018. No. 10 —…

Evobrutinib’s Effects on Macrophages Could Be Beneficial for SLE Treatment, Study Suggests

The investigational compound evobrutinib acts on the immune system by promoting anti-inflammatory behavior of macrophages — immune cells that engulf and digest pathogens — and the death of pro-inflammatory ones, a study reports. This suggests benefits in systemic lupus erythematosus (SLE) and rheumatoid arthritis besides the suppression of B-cells.

Benlysta Maintenance Does Not Change Kidney Function of Lupus Nephritis Patients, Phase 2 Trial Shows

Using Benlysta (belimumab) as a maintenance therapy after Rituxan (rituximab) leads to similar kidney function in patients with lupus nephritis compared with Rituxan alone, according to a Phase 2 clinical trial. The research, “Phase 2 Trial of Induction Therapy with Anti-CD20 (Rituximab) Followed By Maintenance Therapy with Anti-BAFF…