Discovery of New Molecular Mechanism Inhibiting Autoantibody Production May Aid in Lupus Research

Portuguese researchers discovered a new cellular mechanism that may explain how lupus and other autoimmune diseases develop. Their study, “T follicular helper and T follicular regulatory cells have different TCR specificity,” appeared in the journal Nature Communications. The immune system offers protection from pathogens and diseased cells.

SLE Pathogenesis and Imbalances in T-cell Signaling

A recent review summarized the current knowledge on how unbalanced T-cell signaling characterizes systemic lupus erythematosus (SLE) disease. The review study, titled “Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus,” was published in the journal Frontiers in…