The US Food and Drug Administration (FDA) has approved GSK’s new Benlysta subcutaneous formulation. With the approval, Systemic Lupus Erythematosus (SLE) patients will now be able self-inject Benlysta once weekly. In 2011, the FDA approved a formulation of Benlysta that was injectable by healthcare professionals to patients as a weight-based dose…
In a new study entitled “Association of BAFF, APRIL serum levels, BAFF-R, TACI and BCMA expression on peripheral B-cell subsets with clinical manifestations in systemic lupus erythematosus” researchers investigated the role of B cells’ cytokines and receptors in the pathogenesis and development of systemic lupus erythematosus (SLE). The…
In a new study entitled “Treatment of systemic lupus erythematosus patients with the BAFF antagonist “peptibody” blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials” authors determined the safety, tolerability and efficacy of blisibimod, a B cell-activating factor antagonist, in patients with systemic…