Immuno-molecular profiling of systemic lupus erythematosus (SLE) patients has uncovered a personalized molecular signature underlying disease activity that may help scientists develop new tailored therapeutics. The study, “Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients,” was recently published in the journal Cell. SLE, which predominantly affects young women, is…
Salk Institute researchers have shown how FDA-approved rapamycin might have an additional therapeutic effect due to its ability to target the neural damage associated with Leigh syndrome and, potentially, other neurodegenerative diseases. The drug has also been shown to alter the immune system, extend patients’ lifespan, and treat disorders such as lupus…
The American Autoimmune Related Diseases Association (AARDA), celebrating its 25th year, recently announced its #AutoimmuneHeroes for April, which is national volunteer month in the U.S. The AARDA campaign honors those individuals who have supported the group’s work throughout the years. Those spotlighted in AARDA’s #AutoimmuneHeroes campaign are people and organizations contributing…
TxCell SA and Ospedale San Raffaele (OSR) announced the launch of a strategic research and development collaboration that will include efforts to treat lupus nephritis, one of the most severe complications of lupus, using TxCell’s proprietary Chimeric-Antigen-Receptor engineered regulatory T (CAR-Treg) cells, an immunotherapy. Under the agreement, TxCell and OSR will conduct preclinical pharmacology and toxicology…
Defects that disrupt the digestion of dead cells can result in a lupus-like autoimmune disorder, according to a study titled “Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells” and recently published in the journal Nature by scientists at St. Jude Children’s Research Hospital.
Researchers from St. Jude Children’s Research Hospital in Memphis, Tennessee, in collaboration with several other institutions, published findings from a lupus study in which they discovered a new approach to controlling the inflammation and tissue damage that is a hallmark of the chronic autoimmune disorder. The study, “Noncanonical autophagy…
Japanese researchers reported a rare case of idiopathic intracranial hypertension (IIH) accompanying the onset of systemic lupus erythematosus (SLE) in a patient. The study, “Bilateral Abducens Nerve Palsy due to Idiopathic Intracranial Hypertension as an Initial Manifestation of Systemic Lupus Erythematosus,” was published in Internal Medicine. IIH is a syndrome…
Rheumatology Associates, one of the country’s largest rheumatology specialty practices, announced it has recruited Dr. Padmapriya Sivaraman, the 15th board-certified rheumatologist to join the team and increasing office locations to eight with a new office in North Richland Hills, a suburb of Fort Worth, Texas. Rheumatology Associates, founded in 1975,…
Texas researchers found that neutrophils, a type of immune cell, release oxidized mitochondrial DNA, triggering immune reactions in systemic lupus erythematosus (SLE). The findings provide insights into key disease mechanisms, which might be employed in the development of new therapies for this complex and devastating disease. The research team at…
A research team from the University of California, Los Angeles, has shown that certain types of gut bacteria might be crucial in reducing both cancer and inflammation, a finding with long-reaching implications for diseases with an inflammatory component, such as lupus. Intestinal bacterial flora holds both beneficial species and those with…