Corticosteroids and hydroxychloroquine are the most common medications used by patients with systemic lupus erythematosus (SLE) or lupus nephritis (LN), according to a real-world study, which also found very limited use of biologics. The study, “Real World Medication Use in Incident Systemic Lupus Erythematosus and…
Immugenyx, a subsidiary of Hemogenyx Pharmaceuticals, has partnered with Janssen Research & Development, one of the Janssen Pharmaceutical Companies of Johnson & Johnson Innovation, to develop a new humanized mouse model for systemic lupus erythematosus (SLE). The collaboration was announced by Hemogenyx, a biopharmaceutical company devoted…
DN2 B-cells — a subset of immune B-cells that are rare in healthy individuals, but extremely common in patients with systemic lupus erythematosus (SLE) — play a critical role in the production of harmful autoantibodies and lupus activity, a study reports. Conducted by a team of researchers at the Emory…
Transplanting regulatory T-cells — cells that suppress the immune system — resolved skin inflammation in a patient with systemic lupus erythematosus, Phase 1 clinical trial results show. The study, “Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus,” was published in the journal Arthritis &…
Organs affected by autoimmune disease might be able to suppress T-cell function in a manner that is similar to tumors, actively preventing them from causing damage, a study in systemic lupus erythematosus (SLE) shows. The findings, however, suggest that cancer immunotherapies that work to reactivate the immune system could have…
Xencor announced top-line results from its Phase 2 clinical trial testing the candidate antibody therapy XmAb5871 for the treatment of systemic lupus erythematosus (SLE). The antibody seems to help control or reduce lupus disease activity after patients have been…
People with childhood-onset systemic lupus erythematosus (cSLE) develop significant disease-associated damage early in life and have lower quality of life in their adulthood, without achieving medication-free remission, according to a recent Dutch study. The study, “Long‐term clinical outcomes in a cohort of adults with childhood‐onset Systemic Lupus…
Aurinia Pharmaceuticals has completed patient enrollment for its Phase 3 trial that will assess the potential of voclosporin as an add-on to standard treatment regimens in patients with lupus nephritis, the company announced. The enrollment phase was finished ahead of schedule and exceeded expectations, recruiting more participants…
Rates of both ischemic and hemorrhagic strokes in systemic lupus erythematosus (SLE) are affected by the racial and ethnic background of patients, a U.S. study reports, which may help to better identify people most at risk and aid in prevention. Specifically, the study found that black SLE…
Black Africans often have distinct variants of systemic lupus erythematosus compared to white patients, but conventional diagnostic tests can’t detect these variants, say researchers from Scotland’s University of Edinburgh and collaborators from Zimbabwe. Their findings point up the urgency of including specific tests to identify these disease variants, improving…