A study recently published in the journal Nature Immunology revealed a protein that is able to suppress inflammation in the body. The study is entitled “IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal…
Researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH) and the School of Medicine, University of Athens in Greece have recently revealed that hospitalization rates due to serious infections in patients with systemic lupus erythematosus (SLE) have increased significantly.
Researchers at the University of Alabama at Birmingham (UAB) are currently enrolling participants to conduct a study, funded by the Patient-Centered Outcomes Research Institute, aimed at helping minority women suffering from lupus nephritis make an informed decision concerning available therapies. Systemic lupus erythematosus (SLE) is an autoimmune…
A new study showed that mice deficient in regulatory T cells develop systemic autoimmune disease similar to lupus. The study entitled “Regulatory T cell deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease” was published in Arthritis Research & Therapy. Scurfy mice do…
A German team focused on the study of lupus recently evaluated the behavior and lifecycle of long-lived plasma cells (LLPCs), which are a part of the disease systemic lupus erythematosus. The study, “Long-lived Plasma Cells Are Early and Constantly Generated in New Zealand Black/New Zealand White…
Metformin, a metabolic drug approved to treat individuals with type 2 diabetes, may also be useful to treat lupus, according to a new study from University of Florida, published in Science Translational Medicine. The study, “Normalization of CD4+ T Cell Metabolism…
A private supporter of novel lupus research, the Lupus Research Institute (LRI) is celebrating its 15th anniversary with the announcement of a series of grants awarded in recognition of new talent, diversity and excellency. Twelve Novel Research Grants were awarded within the categories of “Strategies for Better, Safer Treatments,” “Innovative Technologies…
In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) network released the SLICC-12, which is a method that can be used to classify systemic lupus erythematosus (SLE). A recent report published in Arthritis Research and Therapy by a group at Linköping University in Sweden described the…
A study published in the journal Pediatric Rheumatology highlighted the importance of recognizing skin lesions in children with juvenile-onset systemic lupus erythematosus. The study is entitled “Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature.” Systemic lupus erythematosus (SLE) is a severe autoimmune disease…
Researchers at the Karolinska University Hospital in Stockholm, Sweden, recently discovered that two specific small proteins are associated with a poor outcome in lupus nephritis patients. The study was published in the journal BMC Immunology and is entitled “IL-17 and…