New research found that a specific set of immune cells named plasmacytoid dendritic cells (pDCs), long believed to cause lupus disease, actually did not contribute to late-stage lupus in a mice model. The paper, which has potential implications for future disease treatment, was published in The Journal of Immunology and is titled…
Environmental factors, like the DNA sequence itself, can alter the way genes are read. These differences, known as epigenetics, may contribute to differences in lupus susceptibility among individuals. Here, a research team at the University of Michigan investigated whether these differences could explain a higher tendency to develop lupus in people of…
The “Moving Forward Together to Fight Lupus” gala dinner celebrated the upcoming merging of the Alliance for Lupus Research (ALR), the Lupus Research Institute (LRI), and S.L.E. Lupus Foundation. The event — the world’s leading lupus fundraiser — collected close to $3 million for groundbreaking research that promises to…
More than 3,000 scientific abstracts spanning the latest in lupus research were presented at the recent American College of Rheumatology (ACR) annual meeting in San Francisco, which brought together nearly 17,000 healthcare providers and researchers in the fields of rheumatology and immunology. According to an article written by Anita Roach, MS, manager…
The division of Nephrology and Hypertension at the Texas Tech University Health Science Center (TTUHSC) El Paso has been invited to collaborate in a multiple-institute, nationwide research consortium that aims to better understand the causes behind, and discover new potential treatments for, lupus nephritis. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease,…
A new and unusual study describes a three- to 32-year follow-up analysis of systemic lupus erythematosus (SLE) patients to understand the number who achieve complete remission (three years) and subsequently remain in remission. The study, titled “Analysis of Complete Remission in Lupus Patients over a period of 32 years,”…
Researchers have identified increased exosomal microRNAs in lupus nephritis patients’ urine, and think it may prove to be a useful, non-invasive disease biomarker. Their paper, titled “Increased Urinary Exosomal MicroRNAs in Patients with Systemic Lupus Erythematosus,” was published in PLOS One. Systemic lupus erythematosus (SLE), a chronic autoimmune disease,…
Delazatide may be effective to control flares in lupus nephritis patients, according to recent data from The Alliance for Children’s Therapeutics (ACT), a pediatric research collaboration between Seattle Children’s Research Institute and the biotech company Kineta, Inc. The results were presented during the recent American College of Rheumatology Annual Meeting in San Francisco,…
Horizon Pharma announced a partnership with the Alliance for Lupus Research (ALR), a non-governmental national health organization, to study the efficacy and safety of RAYOS (prednisone) delayed-release tablets to manage systemic lupus erythematosus (SLE) therapy. RAYOS, known as LODOTRA in Europe, differs from other prednisone formulations because the pharmacokinetic properties of its formulation allow the delayed…
GlaxoSmithKline (GSK) announced positive results from its BLISS-SC Phase 3 study testing the efficacy of Benlysta (belimumab) in patients with active and autoantibody-positive systemic lupus erythematosus (SLE) who are receiving standard therapy. The results, detailed in “A Randomized, Double-Blind, Placebo-Controlled, 52-Week Study of the Efficacy and Safety of Belimumab Administered Subcutaneously Plus Standard…