Air pollution was strongly linked to disease activity in children and adolescents with systemic lupus erythematosus (SLE) in the study, “Air pollution exposure may worsen lupus in children,” presented at the recent European League Against Rheumatism Annual Congress (EULAR 2016) in London. SLE, also known as lupus, is an inflammatory condition…
An associated risk between lupus and cervical cancer has recently been confirmed in a study titled “Cervical dysplasia and cervical cancer in women with rheumatoid arthritis,” presented at the EULAR Congress 2016 June 8-11 in London. Known as systemic lupus erythematosus or SLE, lupus is a condition characterized by chronic autoimmune…
Japanese researchers reported a rare case of idiopathic intracranial hypertension (IIH) accompanying the onset of systemic lupus erythematosus (SLE) in a patient. The study, “Bilateral Abducens Nerve Palsy due to Idiopathic Intracranial Hypertension as an Initial Manifestation of Systemic Lupus Erythematosus,” was published in Internal Medicine. IIH is a syndrome…
GSK has published a new analysis showing that moderate-to-severe systemic lupus erythematosus (SLE) patients treated for five years with Benlysta (belimumab), in combination with standard of care, demonstrated low rates of progression in organ damage regardless of their condition prior to starting therapy.
A collaborative research project conducted between The Scripps Research Institute in La Jolla, California; Yale University in New Haven, Connecticut; and National Biotechnology Center in Madrid, Spain, has identified a small molecule called miR-148a as a key regulator of immune cells, where higher levels appear to cause autoimmune diseases. The paper, “…
New research found that a specific set of immune cells named plasmacytoid dendritic cells (pDCs), long believed to cause lupus disease, actually did not contribute to late-stage lupus in a mice model. The paper, which has potential implications for future disease treatment, was published in The Journal of Immunology and is titled…
The Lupus Initiative (TLI) of The American College of Rheumatology (ACR) was awarded a five-year grant by The Centers for Disease Control and Prevention (CDC). The money will go to supporting development of a national, grassroots program aiming to target individuals with undiagnosed lupus, care providers, and rheumatology healthcare providers. From a diagnostic…
The promise that the field of biomarkers hold for earlier diagnosis and hence superior treatment of systemic autoimmune diseases were the focus of a recent review in Drug Discovery & Development. Systemic autoimmune diseases like rheumatoid (RA), systemic lupus erythematosus (SLE), Sjögren’s syndrome (SjS), polymyositis/dermatomyositis, and systemic sclerosis (SSc) are disorders…
In a recent review paper published in Seminars in Arthritis and Rheumatism entitled “The CD27–CD70 pathway and pathogenesis of autoimmune disease“, researchers examined the role of the CD27 receptor and its ligand protein CD70 in functional changes of autoimmune diseases with particular focus on systemic lupus…