Adding RC18 (telitacicept) to standard therapy significantly lowered disease activity in systemic lupus erythematosus (SLE) patients in a Phase 2b trial, data show. The treatment was also well-tolerated. Researchers at RemeGen, the company developing RC18, presented the findings, “A Human Recombinant Fusion Protein Targeting B…
There is a strong need for multidisciplinary and specific research on childhood-onset systemic lupus erythematosus (SLE) to help better understand the condition and guide treatment, a study by the Childhood Arthritis and Rheumatology Research Alliance (CARRA) and Lupus Foundation of America…
Hoth Therapeutics and Zylö Therapeutics entered into an agreement to jointly develop an endocannabinoid-based treatment for cutaneous lupus erythematosus (CLE), a lupus subtype that affects the skin. Endocannabinoids are cannabis-like molecules naturally produced by the human body, with similar effects to that of medical marijuana. The agreement gives Hoth an…
Two groups of researchers at the University of Houston received a total of $5 million in grants from the National Institutes of Health (NIH) to develop methods for early detection and monitoring of lupus nephritis. Chandra Mohan received a $3 million grant to develop methods for early diagnosis. His group’s research focuses on…
Using the data of pregnant women with systemic lupus erythematosus (SLE), researchers in China created a predictive model that identifies high-risk pregnancies in these women. The model could help clinicians estimate the risk of an adverse outcome early in the pregnancy and start special monitoring and treatment as soon as…
Low-income people with systemic lupus erythematosus (SLE) are at higher risk of getting bone fractures than their non-SLE counterparts. The risk is even greater when lupus nephritis is present, a study suggests. The study, “Comparative Fracture Risks among US Medicaid Enrollees with and without Systemic Lupus Erythematosus,” was published in …
Alcohol intake does not affect the risk of developing systemic lupus erythematosus (SLE), according to a study. The results contradict previous reports about the protective effects of alcohol against SLE. The study, “Alcohol intake and risk of systemic lupus erythematosus: a Mendelian randomization study,” was published in…
BIIB059, an antibody that targets a receptor of plasmacytoid dendritic cells, was well-tolerated and reduced inflammation and skin lesions in systemic lupus erythematosus (SLE) patients, a Phase 1 trial shows. The study, “Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus,” was published in…
Twelve weeks of aerobic exercise improved cardiovascular and respiratory fitness in systemic lupus erythematosus (SLE), but without positive changes in arterial stiffness that was this small study’s main goal. Results also found no increase in signs of inflammation or oxidative stress in the exercise group compared to a control group urged to…
Patients with autoimmune diseases — such as psoriasis, lupus, and arthritis — tend to accumulate collagen, a connective tissue protein, in their blood vessels, which traps cholesterol in arteries and heart tissue, a mouse study has found. These findings begin to explain why these patients have a significantly higher risk for heart…