The bone disorder known as idiopathic osteonecrosis of the femoral head (ONFH) might be caused by high-dose steroid therapy — a common treatment for systemic lupus erythematosus (SLE). A research team at Kyoto University Hospital, Japan, has developed a minimally invasive method to save the thighbone from breaking down,…
XTL Biopharmaceuticals has completed the design of a Phase 2 clinical trial investigating its drug candidate hCDR1 for systemic lupus erythematosus (SLE). The planned international study will be launched this year after the company files its investigational new drug (IND) paperwork with the U.S. FDA. XTL’s lead product hCDR1 is a…
Clinical management of systemic lupus erythematosus (SLE) is challenging, and aims mainly to slow or prevent organ damage, particularly kidney injury. A review, publisThed in the journal ImmunoTargets and Therapy, shows that while immunosuppressive and biological agents form the basis of disease control in lupus, clinicians need…
The excessive inflammatory response that is characteristic of systemic lupus erythematosus (SLE) has now been shown by scientists at University College London to be caused by altered signaling between different kinds of immune cells — leading to a lack of production of regulatory B-cells to control immune responses. The team studied three different immune cells…
A nutritious diet likely helps protects against lupus flare-ups, but contrary to what other studies have indicated, Vitamin D does not seem to make a difference, according to Ph.D. student Cecilia Lourdudoss of Sweden’s Karolinska Institutet. She recently spoke to The Lupus Foundation of America about her study of diet and glucosteroid…
Researchers from Singapore’s leading science institute, A*STAR, found that a group of small noncoding RNAs, called mir-17-92, regulate B-cell function and antibodies in mice. The results may help pave the way for new lupus treatments and other diseases linked to B-cell dysfunction. Antibody-producing B-cells are a crucial part of our defense against pathogens. In autoimmune…
Resolve Therapeutics has successfully completed a dose escalation study of its candidate drug RSLV-132 targeting systemic lupus erythematosus (SLE). RSLV-132 works by breaking down the RNA found in immune complexes. Increasing evidence shows the importance of RNA bound to autoantibody immune complexes to activate the inflammatory pathway regulated by interferon. The drug…
Researchers investigating how diet affects disease activity in systemic lupus erythematosus (SLE) patients, determined via glucocorticoid (GC) treatment, found that dietary vitamin D does not protect against lupus activity while beta-carotene, fatty acid C18:2, and vitamin B6 might have a protective role. Alcohol was also negatively associated with GC treatment, indicating that moderate…
A recent study revealed that mitochondria induce inflammation in lupus through the release of reactive oxygen species into neutrophil extracellular traps (NETs). The research, “Neutrophil extracellular traps enriched in oxidized mitochondria DNA are interferogenic and contribute to lupus-like disease,” offers hope for new lupus treatments. Neutrophils are white blood cells…
A study from the Scripps Research Institute shows that harmful autoimmune responses, as seen in diseases like systemic lupus erythematosus (SLE), can be controlled without compromising the normal activity of the immune system when fighting viruses and bacteria. The key, according…