A large-scale retrospective study found that patients with systemic lupus erythematosus (SLE) may be twice as likely to develop dementia as others of similar age and sex, a finding that may help to improve their care. The study, “Increased Risk of Dementia in Patients with Systemic Lupus Erythematosus: A Nationwide…
Those who develop lupus as youngsters have more severe symptoms and a higher chance of an earlier death, according to a new study. The study in the British journal Lupus suggests that since patients with juvenile-onset systemic lupus erythematosus (JSLE) constitute a high-risk group, doctors need to devote extra attention…
A research study has shown the efficacy and safety of the Benlysta (belimumab), used in combination with other standard of care lupus treatments, such as antimalarials (AM), immunosuppressants (IS) and steroids. The findings may contribute to a better understanding of how Benlysta works as an add-on therapy for systemic lupus erythematosus (SLE). The…
A case-control study found that patients with systemic lupus erythematosus (SLE) show a high prevalence of brain alterations that are clinically associated with cerebral small vessel disease (SVD) — a potential cause of strokes — although a clear link between SLE and SVD was not established. SLE is an inflammatory autoimmune disease…
A case study found that epilepsy and rapid cognitive decline in an 70-year-old man initially masked — and complicated — diagnosing his central nervous system (CNS) lupus, but once the disease was identified and treated with immunotherapy, his neurological symptoms considerably improved. The study, “Neuropsychiatric Systemic Lupus Erythematosus: A Diagnostic Conundrum,” published…
Kezar Life Sciences, a San Francisco-based company focused on the development of therapies targeting protein homeostasis, recently initiated a Phase 1 clinical trial assessing KZR-616, a potential treatment for multiple autoimmune and inflammatory diseases, including lupus. Together with a medical team in Australia, the study will be performed in a…