Foods Rich in the Omega-3 Fatty Acid, DHA, May Work Against Lupus Trigger

Foods Rich in the Omega-3 Fatty Acid, DHA, May Work Against Lupus Trigger

Consumption of foods rich in docosahexaenoic acid (DHA), an omega-3 fatty acid, can prevent the onset of systemic lupus erythematosus (SLE) and possibly other autoimmune diseases, according to a study published in the journal PLoS One.

The study, by Melissa Bates from Michigan State University and colleagues, is titled “Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption.

Lupus is a genetic disorder characterized by an abnormal immune system response (autoimmune disease). Certain factors have been identified as SLE triggers, such as inhaling crystalline silica or sun exposure. Quartz is the most common and dangerous form of crystalline silica, and people are often exposed to it when they breathe in mineral dust from agricultural, construction, and mining activities.

Diet is another factor that influences susceptibility to autoimmune disorders, and omega-3 fatty acids such as docosahexaenoic acid (DHA) have a recognized anti-inflammatory action. DHA can be found in fatty, cold-water fish, like salmon, sardines and anchovies, as well as in fish like halibut and tuna, and in algae or fish oil supplements.

The objective of the study was to investigate whether DHA could have a beneficial role in controlling the excessive response of the immune system in female mice with SLE induced by silica inhalation. To do so, mice were fed with DHA-enrich diets in different percentages of DHA (estimated to be similar to human consumption of this molecule) for one month, after which, SLE lesions in their lungs and kidneys were analyzed.

According to the researchers, 97 percent of the lung lesions were improved by DHA consumption, an effect that increased with DHA dose.

“Cells in the lung can gobble up the silica, but it’s so toxic, it kills these cells,” Jack Harkema, one of the study’s authors, said in a news release. “When they die, signals are sent out to the immune system that something is wrong. The body then produces such a strong response that it also starts to target healthy cells.”

But the mechanism by which DHA is able to prevent SLE remains unknown. The team believes that DHA may change how cells in the immune system react to silica in the lungs, and work to control their response so that it is not exaggerated. DHA may also help immune cells to remove silica from the lungs without dying, and without causing an over-reactive inflammatory response.

“What we do know is this study is a clear indication that eating DHA can prevent this one type of environmental triggering of lupus,” said James Pestka, the study’s senior author. “It can suppress many of the disease’s signaling pathways, which current drugs on the market now try to target and treat.”

More studies are necessary to understand whether DHA-enriched foods can indeed be a practical and low-cost strategy to prevent or delay autoimmune diseases in people, as well as identifying the mechanism of action of this molecule.


  1. Suzanne Zeleznik says:

    I eat salmon and tuna at least 5 times a week– in lunches: brown rice sushi; and broiled for dinner. I’ve lost over 50 lbs by following a Mediterranian diet + no red meat. I do not use salt. But My Lupus is as active as ever!! I eat well, and get to the gym, but have seen No lessening of Lupus symptoms!

    • SB says:

      Try compounded Low Dose Naltrexate-research it online. I only take .5 mg and it helps. Pharmacies only sell it in 50 mg so that’s why you have to get Naturopathic Dr to give prescription to compound it. It is FDA approved.

  2. Bruce Merklin says:

    For me it was sulfites and nitrates that brought on lupus flares (within hours, every time). Most people can detoxify these toxins, which are in more and more foods, in ever greater quantities, often without labeling. Try cutting out wine, beer, all canned and dried fruits, fruit juices, processed meats, and lunch meats. You might also have food intolerance, most likely would be milk, wheat, soy, or peanuts. An elimination diet is the only way to test for that (doctors only test for allergies). You can find much info on elimination diets on the web. A lot of trouble to go to? Yes, but lupus is serious, and painful. So don’t wait for a doctor to give you a magic pill. There is none. And if environmental chemicals are the cause of lupus, there never will be a pill cure. Hope I have helped (PS – my lupus has been gone, 100%, for almost a year now. Took me several years to figure out what was causing it. BRUCE in Norway

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