Exagen is teaming up with a research lab at the University of Washington’s School of Medicine (UW Medicine) to better understand the workings of the immune system in lupus and rheumatoid arthritis. The collaboration involves the lab of Christian Lood, PhD, an assistant professor in the division…
Researchers have identified a factor that controls immune cells’ entry into joints, which leads to arthritis in diseases such as systemic lupus erythematosus (SLE). Though they are studying other factors in the process, they believe these findings could lead to new treatments that are more effective in preventing arthritis. “Inflammatory arthritis is caused when immune…
Large-scale analysis of genome-wide gene expression signatures allows researchers to discriminate between patients with active and inactive systemic lupus erythematosus — and could help physicians in adjusting treatment to control disease activity while minimizing the risk of side effects. The study reporting the method, “Clinical Application of a Modular…
In a landmark study, principal researcher Virginia Pascual at the Baylor Institute for Immunology Research, and colleagues, investigated the molecular diversity of lupus and found that a personalized immuno-monitoring approach allows for classification of patients into specific disease groups. Researchers believe these results may explain why lupus clinical trials have a low success rate…
A recent study revealed that mitochondria induce inflammation in lupus through the release of reactive oxygen species into neutrophil extracellular traps (NETs). The research, “Neutrophil extracellular traps enriched in oxidized mitochondria DNA are interferogenic and contribute to lupus-like disease,” offers hope for new lupus treatments. Neutrophils are white blood cells…
A team led by researchers at The University of Texas MD Anderson Cancer Center recently revealed new insights into the mechanisms underlying the development of autoimmunity in animal models of systemic lupus erythematosus (SLE). The study was recently published in the journal Cell Reports and is…