Pulmonary arterial hypertension (PAH) is a prevalent comorbid factor in systemic lupus erythematosus (SLE) patients, significantly increasing mortality outcomes. This is the conclusion of a recent review titled “Survival and prognostic factors of systemic lupus erythematosus-associated pulmonary arterial hypertension: A PRISMA-compliant systematic review and meta-analysis,” published in the journal…
News
Xencor announced the beginning of two Phase 2 clinical trials testing its drug candidate, XmAb5871, to treat systemic lupus erythematosus (SLE) and IgG4-related disease (IgG4-RD), a rare fibro-inflammatory autoimmune disorder. In both trials, a first patient has already received an initial testing dose. XmAb5871 is a monoclonal antibody that targets both CD19 and the FcγRIIb…
ImmuPharma PLC announced that Phase 3 clinical studies evaluating the safety and efficacy of Lupuzor — its lead compound to treat lupus – are now getting underway and enrolling patients in Europe, and continuing to enroll people in the U.S., where first dosing has already begun. The pivotal trial, titled “A 52-Week,…
The excessive inflammatory response that is characteristic of systemic lupus erythematosus (SLE) has now been shown by scientists at University College London to be caused by altered signaling between different kinds of immune cells — leading to a lack of production of regulatory B-cells to control immune responses. The team studied three different immune cells…
Corbus Pharmaceuticals Holdings, Inc., announced it will soon begin a Phase 2 clinical trial to test the efficacy, safety, tolerability, and biologic effects of its drug candidate, Resunab, in patients with systemic lupus erythematosus (SLE). Resunab is a first-in-class, synthetic oral endocannabinoid-mimetic drug that preferentially binds to the CB2 receptor expressed on activated…
A nutritious diet likely helps protects against lupus flare-ups, but contrary to what other studies have indicated, Vitamin D does not seem to make a difference, according to Ph.D. student Cecilia Lourdudoss of Sweden’s Karolinska Institutet. She recently spoke to The Lupus Foundation of America about her study of diet and glucosteroid…
Israel-based XTL Biopharmaceuticals, a clinical stage biotech company that focuses on the development of new drugs for the treatment of autoimmune diseases, has announced that its lead drug candidate, hCDR1, has been granted a patent by the Hungarian Intellectual Property Office. The patent, “Synthetic Human Peptides and Pharmaceutical Compositions Comprising…
Aurinia Pharmaceuticals recently announced the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to voclosporin, a next-generation calcineurin inhibitor under development to treat patients with lupus nephritis (LN) and other autoimmune diseases. LN is a kidney inflammation caused by systemic lupus erythematosus (SLE) in which patients may develop proteinuria,…
Researchers from Singapore’s leading science institute, A*STAR, found that a group of small noncoding RNAs, called mir-17-92, regulate B-cell function and antibodies in mice. The results may help pave the way for new lupus treatments and other diseases linked to B-cell dysfunction. Antibody-producing B-cells are a crucial part of our defense against pathogens. In autoimmune…
Immunovia AB recently announced it has entered into a collaboration with a large multinational life science company to jointly conduct trials to expand the application of IMMray, a technology platform based on antibody microarray analysis, to include autoimmune diseases like systemic lupus erythematosus (SLE). The company was not otherwise…
Recent Posts
- Twin Phase 3 studies recruiting adults with lupus skin problems in US, Canada
- Understanding how menopause can affect our lupus symptoms
- Discovering a role the vagus nerve plays in chronic pain management
- Recognizing patterns is one of my greatest weapons against lupus flares
- Flaws on the X chromosome may directly trigger lupus in women