Kadmon announced the publication of data from preclinical studies supporting its oral drug candidate, KD025, a small molecule ROCK2 inhibitor, as a potential treatment for autoimmune diseases such as systemic lupus erythematosus (SLE). The data indicated that KD025 worked to inhibit the rho-associated coiled-coil kinase 2 signaling pathway (ROCK2), reducing the development and function…
The Office of Minority Health has awarded the American College of Rheumatology’s (ACR) The Lupus Initiative (TLI) a one-year $335,000 grant to continue to expand its national education program by developing an expert-informed model specifically focused on improving health outcomes in lupus patients. “This model is the first of its kind to…
Novato-based Mount Tam Biotechnologies announced the U.S. Patent and Trademark Office has issued a key patent for the company’s lead systemic lupus erythematous (SLE) drug candidate, TAM-01, an innovative small-molecule modulator of the mTOR pathway that plays an important role in regulating the cell cycle. The patent, owned by The Buck Institute…
The Alliance for Lupus Research (ALR), the Lupus Research Institute (LRI) and the S.L.E. Lupus Foundation have merged to form the largest private sector organization dedicated to advance lupus research – The Lupus Research Alliance (LRA). With a new board of directors in place, the Lupus Research Alliance is geared…
A new assessment tool, called the lupus impact tracker or LIT, is valid and can be used by doctors in the clinic to track symptoms in systemic lupus erythematosus (SLE) and better discuss the disease with patients, researchers report. The study evaluating the tool, “Prospective Validation of the Lupus Impact Tracker:…
Non-Europeans more often carry genes increasing the likelihood of developing systemic lupus erythematosus (SLE), explaining the higher disease rates observed in people outside of Europe, according to a report by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ and King’s College London.
The Lupus Foundation of America (LFA) was awarded a one-year, $1 million grant from the Office of Minority Health at the Department of Health and Human Services (HHS) to develop an education program on clinical trials that educates and recruits minorities and the disadvantaged, especially groups that are underrepresented in clinical research.
Air pollution was strongly linked to disease activity in children and adolescents with systemic lupus erythematosus (SLE) in the study, “Air pollution exposure may worsen lupus in children,” presented at the recent European League Against Rheumatism Annual Congress (EULAR 2016) in London. SLE, also known as lupus, is an inflammatory condition…
Men and women respond differently to infections, a gender difference in immune responses that could help explain why some autoimmune diseases, such as systemic lupus erythematosus (SLE) and multiple sclerosis, are more likely to afflict one sex than the other. A review article by Sara Reardon, a science writer, explored this idea. It was published in …
Anthera Pharmaceuticals reported that the company’s Phase 3 clinical trial of blisibimod in patients with severe systemic lupus erythematosus (SLE) began recently with researchers screening the study’s first patient. Called CHABLIS 7.5, the study is the second Phase 3 trial to explore the drug in lupus patients with and without lupus…