Childhood-onset systemic lupus erythematosus (cSLE) may be linked to the development of eye problems such as uveitis that can cause blindness, a study says. The research, “Uveitis In Childhood-Onset Systemic Lupus Erythematosus Patients: A Multicenter Survey,” was published in the journal Clinical Rheumatology. Nearly a third of SLE…
Systemic lupus erythematosus (SLE) patients with signs of organ damage when first hospitalized, even if they don’t have active disease, are likely to have poorer outcomes, researchers in China reported. Mortality risk was particularly high in SLE patients with neuropsychiatric and cardiopulmonary complications or with evidence of kidney failure. But…
GlaxoSmithKline (GSK) announced that it has filed a New Drug Application with Japan’s regulatory health agency requesting that belimumab — widely known under the brand name Benlysta — be approved to treat adults with active, autoantibody-positive, systemic lupus erythematosus (SLE, lupus) who do not respond to standard therapy. GSK seeks approval…
The U.S. Food and Drug Administration (FDA) has granted fast-track status to Neovacs’ vaccine IFNα Kinoid, which is being evaluated as a treatment for systemic lupus erythematosus (SLE). The vaccine is aimed at blocking interferon alpha, or IFNa, a protein linked to lupus. The more IFNa that patients have, the…
Prolonged treatment with Benlysta (belimumab) offers safe and effective control of disease activity, improves life quality and eases fatigue in patients with active, autoantibody-positive systemic lupus erythematosus (SLE), according to seven-year clinical trial results released by GSK, the drug’s developer. These findings come from a continuation study of patients who completed the Phase…
The Lupus Research Alliance awarded a Target Identification in Lupus grant to a team of investigators led by Kerstin Nündel, PhD, of the University of Massachusetts Medical School, to fund their research projects on the disease. The $574,000 three-year grant will be used to study how a type of…
Researchers have identified novel biomarkers for lupus nephritis (LN), a disease that affects several patients with systemic lupus erythematosus (SLE), according to a study published in the journal Arthritis & Rheumatology. The authors reported these biomarkers can accurately indicate disease development and predict therapeutic effectiveness. The study is titled “…
Consumption of foods rich in docosahexaenoic acid (DHA), an omega-3 fatty acid, can prevent the onset of systemic lupus erythematosus (SLE) and possibly other autoimmune diseases, according to a study published in the journal PLoS One. The study, by Melissa Bates from Michigan State University and colleagues, is titled “Silica-Triggered…
Patients with systemic lupus erythematosus (SLE) may be at increased risk of incident respiratory failure, according to a nationwide study by Taiwanese researchers. The study, “Effect of Systemic Lupus Erythematosus on the Risk of Incident Respiratory Failure: A National Cohort Study,” published in the journal PLoS One, also…
The results of a Phase 2/3 trial at two hospitals in the U.K. comparing the effectiveness of Xarelto (rivaroxaban) and Coumadin (warfarin) in the treatment of patients with thrombotic antiphospholipid syndrome (APS), with or without systemic lupus erythematosus, showed that Xarelto can be a safe and effective option for patients with…