What to Know About Lupus and Genetics

Lupus is a complex, autoimmune disease that causes the body to attack its own healthy tissue. There are many causes, and according to lupus.org, could include anything from inherited genes, environmental exposure, hormones, and more.

MORE: What to know about lupus and the immune system

However, it’s believed that the main causes of lupus are linked to genetics. Although there isn’t one particular gene that’s been specifically linked to the development of the disease, there are often multiple cases in families. It’s also been shown that if one twin develops lupus, the likelihood of the other twin developing the disease is high, strongly suggesting a genetic link in the cause of the disease.

On the other hand, most cases of lupus are what are referred to as sporadic, meaning there is no known family history of the disease. However, if there is a case of lupus in a family, it’s highly likely that there are other cases of different autoimmune diseases in that same family.

There is also evidence that suggests certain ethnic groups have a higher chance of developing lupus, which could be due to common genes.

MORE: Learn more about other autoimmune diseases here

Lupus News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.


  1. Robert Darnell says:

    My dad had psoriasis really bad. My maternal aunt had lupus and died at age 63. I have been diagnosed with SLE and Psoriatic Arthritis. I did test positive for RA and scleroderma, but currently not being treated specifically for those. I have moderate neuropathy, hypopituitarism, and autoimmune narcolepsy all related to CNS involvement of SLE. My CSF had abnormal protein in it that points to autoimmune disease. I’m only 46, but feel like an old man. Just 6 years ago I was riding 100 miles a day on my bicycle and doing anything that I wanted to. That’s like another lifetime ago. I can barely stand to put my feet on the floor these days and am so limited. I hurt 24/7, and my memory is terrible.

    • dc says:

      Robert, I’m in the same boat that you are ! I hate it so I certainly understand your post. I’ve owned my own business but now work from a home office with a secretary just to keep the doors open. Can’t visit clients except by phone or at night ! I do still try to travel but got very sick in Ireland which was quite scary ! I was dx’d with Sjogren’s in 2000, lupus in ’06, Hashimoto’s in ’89, MCTD, Reynaud’s, and PIDD (primaryimmun0globulin deficenecy disease) in ‘2016 which will require life long 2X per month infusions ! Phooey ! but, thank God, they found it ! I’m sorry you lost your biking, I lost my landscaping and gardening ! (farmer’s daughter) ! Now, I try to hire it done and give the crew a scetch of what is where and how tall to clip it, etc. Not as much fun but I still enjoy strolls in the evening around the gardens to see what is blooming and who needs to be moved cause they’re not happy, etc. You can only do what you can do now. I think I see a fellow overachiever and I understand. It’s hard to be so tired but I can no longer “push through” the fatigue and I just have to give my body the rest required or I wind up in the hospital and last time I was there, I got MRSA !! So, I’m trying to adjust and those who don’t understand just need to educate themselves ’cause they couldn’t do any better. Blessings in your journey, dc

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