6 Common Symptoms of Lupus Nephritis


Lupus is an autoimmune disease that can attack any part of the body, including internal organs. The kidneys are commonly affected in lupus patients and can lead to the development of lupus nephritis. We’ve put together a list of five of the most common symptoms of lupus nephritis using information from Web MD and kidney.org.

High Blood Pressure
If the blood vessels in the kidneys become damaged due to lupus, they could stop removing waste and extra fluid leading to a build-up of fluid in the body. This extra fluid makes the blood vessels have to work even harder and raises blood pressure. (Source: NIH)

Blood in the Urine
Lupus nephritis can cause the small blood vessels (glomeruli) in the kidneys to bleed which will leach into the urine. Urine may come out pinkish or brown when it’s tinged with blood.

Protein in the Urine
If the urine appears foamy it could be because there is protein present. The glomeruli may also leak protein into the urine.

MORE: Read our list of nine important facts you may not know about lupus

Swelling in the body, usually the legs, ankles, and feet is due to a build-up of excess fluid which the kidneys are not effectively getting rid of. The swelling can also appear around the eyes.

Weight Gain
Sufficient excess fluid which the kidneys are unable to get rid of may result in weight gain.

Frequent Urination
Having to visit the bathroom more than usual, particularly during the night, could indicate that you have a problem with your kidneys.

MORE: Read about five serious complications that can develop due to an autoimmune disease

Lupus News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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  1. Shaimaa says:

    all of this symptoms happened to me during my pregnancy in the first trimester.I’m still suffering from the weight issue although I’m on medication and no more fluid retention and have control blood pressure.

  2. Diana says:

    Hi, I am a 21 year old female, I was recently diagnosed with a heart condition (Postural Orthostatic Tachycardia Syndrome) and was put on meds called Carloc and Mestinon. A few weeks ago I ended up in hospital with a bad migraine (which I have been getting for 16 years) the doctor said that my BP was very high so I went back to the Doctor that put me on the heart meds and he did a 24 blood pressure test where the results came back and my BP was significantly high and was 220/160 at one point in the middle of the night while I was asleep. Due to these results the Doctor put me on Prexum to lower my BP. Since then I have had severe muscle pain in my neck and back (I do usually get a sore neck from migraines but it has never been this bad) my elbows and jaw has been clicking a lot and every now and then my wrists and elbows hurt a bit. I went to see a Rheumatologist who did blood tests and my ANA results came back 1:80 and he said that I need to get another test in 3 months, he didn’t seem concerned though as I didn’t really explain all my symptoms to him as I didn’t think they were important but now they are staring to get worse. I’m struggling to tell which symptoms are from my POTS and which are new symptoms. For the last three weeks I have noticed that I’ve had ulcers on my tongue but they are not sore at all. I have had bad neck and back pain and clicking joints. These are only recent symptoms. Please advise me on what to do? Whether I should just wait three months for my next blood test or maybe go to the doctor sooner? I don’t know if I’m just overthinking this or being a bit dramatic but I don’t know what to do. Help would be much appreciated. Thank you

    • Diana says:

      I forgot to add; my eyes have been very dry recently and I have been very thirsty and drunk a lot of water but still have a dry throat and still feel thirsty.

  3. Sandra says:

    Hi Diana. This sounds like an early onset of Sjogren disease, an autoimmune disorder. Your ANA titer is positive, but very low, borderline, it doesn’t have to mean anything. Have you analysed any other antibodies? You might check something called the “Nemecheck protocol”, there is a FB group with support system and throughout guides. Good luck!

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