People with systemic lupus erythematosus (SLE) have a unique mix of bacteria on their tongue compared with healthy people, according to a Chinese study. Bacteria diversity correlated with disease activity, but also with recovery after treatment. The findings suggest oral bacteria “may be a therapeutic target for exploring new…
Adding Saphnelo (anifrolumab-fnia) to standard therapy in people with moderate to severe systemic lupus erythematosus (SLE) is linked to reaching a state of low disease activity faster and more frequently, according to an analysis of data from two Phase 3 clinical trials. This low disease activity state was sustained for…
Almost half of women with systemic lupus erythematosus (SLE) who underwent assisted reproductive therapy (ART) became pregnant, and 83.3% of them had a successful delivery, a large retrospective study shows. Only a small number of women experienced lupus flares, but ART was linked to a higher incidence of premature…
Women with systemic lupus erythematosus (SLE) whose disease went into remission right before becoming pregnant show better outcomes in the post-partum period, including a lower flare rate, according to a two-year follow up study. These findings highlight how “planned pregnancy counseling is fundamental when managing SLE patients,” the researchers wrote.
When given on top of standard therapy, zetomipzomib led to clinically significant reductions in urine protein levels, a marker of kidney impairment, in systemic lupus erythematosus (SLE) patients with active lupus nephritis, a severe form of lupus that causes kidney damage. That’s according to full data from the now…
The incidence of systemic lupus erythematosus (SLE) has increased in the U.S. the past four decades, a recent study shows. Study data also indicated the increased incidence seen during that time was significantly higher among racial and ethnic minority populations. “As the US population grows more diverse, we might continue…
Adding the experimental oral therapy voclosporin to standard treatment is safe, and its use more than doubles complete kidney responses in people with lupus nephritis, results from the Phase 3 AURORA study show. Aurinia Pharmaceuticals, the company developing voclosporin, plans to finish its rolling application to the U.S. Food…
More stringent thresholds in the Cutaneous Lupus Activity and Severity Index (CLASI), a common tool to assess disease progression and treatment response in cutaneous lupus erythematosus (CLE), can better identify patients with clinical improvements, a study reports. Its findings also suggest that people who develop CLE early in…
While people with systemic lupus erythematous lupus (SLE) are experiencing fewer eye complications directly linked to the disease, treatment-induced eye toxicity and age-related eye complications are becoming more frequent, a single-center study shows. The study, “Ocular involvement in systemic lupus erythematosus patients: a paradigm shift based…
Elevated blood levels of a marker called galectin-9 may help identify people with systemic lupus erythematous lupus (SLE) who have more active disease and organ damage, a study suggests. The study “Galectin-9 as a biomarker for disease activity in systemic lupus erythematosus” was published in the journal…