Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a misdirected attack of the immune system against the body’s own organs. Disease origins are quite complex and still not fully understood, hampering SLE’s cure. Due to its systemic nature, SLE causes a wide array of clinical symptoms, complicating its…
In a recent study, researchers from University Hospital of Split, Croatia investigated the relationship between Vitamin D, Interferon-gamma (INF-gamma) and Estradiol in females of childbearing age with inactive Systemic Lupus Erythematosus (SLE). The paper entitled “Relationship between vitamin D, IFN-c, and E2 levels in systemic lupus erythematosus” was…
A team of researchers from Brazil and Israel review in a recent paper the evidences linking systemic lupus erythematosus and periodontal disease. The study entitled “Possible evidence of systemic lupus erythematosus and periodontal disease association mediated by Toll-Like Receptors-2 and 4 (TLR2, TLR4)” was published in the…
In a recent study entitled “Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous” published in the Scientific Reports journal, a team of researchers from India presented a robust method of identifying monocytes, a type of white blood cell that is involved in different…
A team of researchers from Argentina and the U.S. have explained how flare-ups in multiple sclerosis patients are intimately related to their melatonin levels, a natural occurring hormone that regulates our sleep/wake cycles – circadian rhythms. The team showed that melatonin alleviates disease symptoms by resetting the immune system, with these…
In a recent review paper entitled “Defects in germinal center selection in SLE”, published in Frontiers in Immunology, the authors discuss the mechanisms leading to a deficient selection of auto-reactive B cells in lymph nodes of patients with Systemic Lupus Erythematosus (SLE). Systemic…